BD-3 蛋白, Human

BD-3 Protein, Human is an antibacterial peptide that exhibits antibacterial activities towards Gram-negative and Gram-positive bacteria as well as an ability to act as a chemo-attractant.

人β-防御素-3 (HβD-3) 是宿主防御肽家族中最新发现的成员。HβD-3 已被证明对革兰氏阴性和革兰氏阳性细菌具有抗菌活性，并且具有作为化学引诱剂的能力。HβD-3 对于结构和功能研究以及可能的药物应用特别感兴趣。它也是已鉴定的具有寡聚化能力的人类防御素之一^[1]。

The ED₅₀ is <30 μg/mL as measured by anti-microbial activity against E.coli, corresponding to a specific activity of >33.3 units/mg.

Human

E. coli

Tag Free

P81534 (G23-K67)

55894  [NCBI]

GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK

Approximately 5.2 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against 20 mM PBS, pH 7.4, 130 mM NaCl.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Dhople V, et al. The human beta-defensin-3, an antibacterial peptide with multiple biological functions. Biochim Biophys Acta. 2006 Sep;1758(9):1499-512.  [Content Brief]