2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. L-701324

L-701324 是一种口服有效的 NMDA 受体拮抗剂，通过阻断其甘氨酸 B 结合位点来拮抗 NMDA 受体的活性。L-701324 与大鼠脑膜具有高亲和力 (IC50=2 nM)。L-701324 具有抗抑郁活性。

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L-701324 Chemical Structure

L-701324 Chemical Structure

CAS No. : 142326-59-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥632
In-stock
5 mg ￥710
In-stock
10 mg ￥1150
In-stock
50 mg ￥3350
In-stock
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200 mg   询价  

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L-701324 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity[1][2][3].

体内研究
(In Vivo)

L-701324 (5-10 mg/kg; i.p.; once) exhibits antidepressant-like potential in the forced swim test (FST) and tail suspension test (TST) without affecting the locomotor activity of mice[1].
L-701324 (5-10 mg/kg; i.p.; daily, for 2 weeks) produces strong antidepressant-like effects in the chronic unpredictable mild stress (CUMS) model of depression and prevents the CUMS-induced decreases in eurogenesis and the BDNF signaling cascade in the hippocampus[1].
L-701324 (2.5-5 mg/kg; p.o.; once) inhibits NMDA receptor activity via a blockade of the NMDA/glycine-sensitive site at the NMDA receptor is accompanied by a reduction of anxiety-like behavior in both non-conditioned and conditioned conflict behavior situations[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 J mice in the chronic unpredictable mild stress (CUMS) (7 weeks of age) [1]
Dosage: 5 and 10 mg/kg
Administration: Intraperitoneal injection; daily, for 2 weeks
Result: Reduced the immobility of C57BL/6 J mice.
Increased the expression of BDNF, pTrkB and pCREB in the hippocampus.
Animal Model: Male C57BL/6 J mice in the forced swim test (FST) and tail suspension test (TST) (7 weeks of age)[1]
Dosage: 5 and 10 mg/kg
Administration: Intraperitoneal injection; once
Result: Reduced the immobility of C57BL/6 J mice in the FST and TST.
Animal Model: Male Sprague-Dawley rats (280-300 g)[2]
Dosage: 2.5 and 5 mg/kg
Administration: Oral administration; once
Result: Increased in the percentage of time spent in the open arm in a dose-dependent.
Increased punished responding in the Vogel's conflict test in a dose-dependent fashion.
分子量

363.79

Formula

C21H14ClNO3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 34 mg/mL (93.46 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7488 mL 13.7442 mL 27.4884 mL
5 mM 0.5498 mL 2.7488 mL 5.4977 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.92%

COA (191 KB) LCMS (99 KB)

产品使用指南 (1538 KB)
参考文献

L-701324 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7488 mL 13.7442 mL 27.4884 mL 68.7210 mL
5 mM 0.5498 mL 2.7488 mL 5.4977 mL 13.7442 mL
10 mM 0.2749 mL 1.3744 mL 2.7488 mL 6.8721 mL
15 mM 0.1833 mL 0.9163 mL 1.8326 mL 4.5814 mL
20 mM 0.1374 mL 0.6872 mL 1.3744 mL 3.4360 mL
25 mM 0.1100 mL 0.5498 mL 1.0995 mL 2.7488 mL
30 mM 0.0916 mL 0.4581 mL 0.9163 mL 2.2907 mL
40 mM 0.0687 mL 0.3436 mL 0.6872 mL 1.7180 mL
50 mM 0.0550 mL 0.2749 mL 0.5498 mL 1.3744 mL
60 mM 0.0458 mL 0.2291 mL 0.4581 mL 1.1453 mL
80 mM 0.0344 mL 0.1718 mL 0.3436 mL 0.8590 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-701324142326-59-8L701324L 701324iGluRIonotropic glutamate receptorsglycine B binding siteantidepressantbrain membranestail suspension testforced swim testchronic unpredictable mild stressInhibitorinhibitorinhibit

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目录号：
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