2. Immunology/Inflammation GPCR/G Protein
  3. COX Prostaglandin Receptor
  4. Ufenamate

Ufenamate  (Synonyms: 氟芬那酸丁酯; Flufenamic acid butyl ester; Butyl flufenamate)

目录号: HY-100009 纯度: 99.89%
COA 产品使用指南

摩尔计算器

Ufenamate (Flufenamic acid butyl ester) 是一种基于邻氨基苯甲酸的抗炎试剂，可用于皮肤疾病的研究，例如急慢性湿疹，接触性皮炎，尿布性皮炎，粟疹和特应性皮炎。Ufenamate 具有一定的光保护作用，在光老化模型中减轻皮肤红斑肿胀程度，下调 COX-2 表达水平，并且可以通过分泌 BMP2 促进小鼠颅骨缺损愈合。

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Ufenamate Chemical Structure

Ufenamate Chemical Structure

CAS No. : 67330-25-0

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥500
In-stock
5 mg ￥450
In-stock
10 mg ￥500
In-stock
50 mg ￥650
In-stock
100 mg ￥790
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Ufenamate 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug that can be used in the study of skin diseases such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliary rashes and atopic dermatitis. Ufenamate has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging model, downregulates the expression level of COX-2 and can promote the healing of mouse skull defects by secreting BMP2[1][2][3][4].

IC50 & Target

COX-2

 

体内研究
(In Vivo)

Ufenamat (2 µL/cm2，软膏涂抹，单次剂量) 在大鼠中不适合干性皮肤[2]。
Ufenamate (软膏涂抹，单次剂量) 具有一定的光保护作用, 在小鼠光老化模型中减轻皮肤红斑肿胀程度，下调 COX-2 表达水平[3]。
Ufenamat (软膏涂抹，6 和 8 周) 促进小鼠颅骨损伤愈合[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UV-induced acute sunburn model, photoaging model and skin squamous cell carcinoma model in SKH-1 hairless mice[3]
Dosage: Ointment application
Administration: Ointment application; single dose; 30 min
Result: Inhibited acute swelling and redness caused by UV irradiation and reduced COX-2 expression.
At 12 weeks of irradiation, skin aging was alleviated, the collagen density of the dermis was higher, the expression of Bcl-2 was weakened, and the expression of Bax and Caspase 3 was enhanced.
At 28 weeks of irradiation, the appearance of tumors was delayed.
Animal Model: Intact and damaged skin of rats[2]
Dosage: 2µL/cm2
Administration: Ointment application; single dose
Result: Applied on the damaged skin, contained in the epidermis was approximately 50% and 25% of that in the intact skin after LP and water, respectively, with the content being 5 times and 10 times higher than in the intact skin.
Permeated UF five times more than LP in the intact skin. Reduced significantly the permeation of UF by both LP and water due to the defatting effect of SC.
Animal Model: Skull defect mice[4]
Dosage: Ointment application
Administration: Ointment application; 6 weeks and 8 weeks
Result: Promoted the formation of new bone in the defect area, and the effect was stronger after 8 weeks than at 6 weeks, improving the BV/TV and BMD in the defect area.
分子量

337.34

Formula

C18H18F3NO2
CAS 号
性状

液体（密度：1.2230 g/cm3）

颜色

Colorless to light yellow

中文名称

氟灭酸丁酯；乌芬那酯；氟芬那酸丁酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 44 mg/mL (130.43 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9644 mL 14.8218 mL 29.6437 mL
5 mM 0.5929 mL 2.9644 mL 5.9287 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Ufenamate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9644 mL 14.8218 mL 29.6437 mL 74.1092 mL
5 mM 0.5929 mL 2.9644 mL 5.9287 mL 14.8218 mL
10 mM 0.2964 mL 1.4822 mL 2.9644 mL 7.4109 mL
15 mM 0.1976 mL 0.9881 mL 1.9762 mL 4.9406 mL
20 mM 0.1482 mL 0.7411 mL 1.4822 mL 3.7055 mL
25 mM 0.1186 mL 0.5929 mL 1.1857 mL 2.9644 mL
30 mM 0.0988 mL 0.4941 mL 0.9881 mL 2.4703 mL
40 mM 0.0741 mL 0.3705 mL 0.7411 mL 1.8527 mL
50 mM 0.0593 mL 0.2964 mL 0.5929 mL 1.4822 mL
60 mM 0.0494 mL 0.2470 mL 0.4941 mL 1.2352 mL
80 mM 0.0371 mL 0.1853 mL 0.3705 mL 0.9264 mL
100 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.7411 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ufenamate67330-25-0Flufenamic acid butyl ester Butyl flufenamate氟灭酸丁酯乌芬那酯氟芬那酸丁酯COXProstaglandin ReceptorCyclooxygenaseanthranilicanti-inflammatoryskindiseaseseczemacontactdermatitisdiapermiliariaatopicInhibitorinhibitorinhibit

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