2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. CCR1 antagonist 12

CCR1 antagonist 12 (Compound 12) 是 CCR1 的拮抗剂，对人类 CCR1 的 IC50 为 3 nM。CCR1 antagonist 12 抑制 CCL3 诱导的跨孔趋化作用，IC50 为 0.009 µM。CCR1 antagonist 12 在大鼠模型中表现出良好的药代动力学特征。

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CCR1 antagonist 12 Chemical Structure

CCR1 antagonist 12 Chemical Structure

CAS No. : 921208-19-7

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CCR1 antagonist 12 相关抗体

Top Publications Citing Use of Products

查看 CCR 亚型特异性产品:

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CCR1 antagonist 12 (Compound 12) is an antagonist for CCR1 with IC50 of 3 nM for human CCR1. CCR1 antagonist 12 inhibits CCL3-induced transwell chemotaxis with an IC50 of 0.009 µM. CCR1 antagonist 12 exhibits good pharmacokinetic characters in rats model[1].

IC50 & Target

CCR1

3 nM (IC50)

分子量

487.95

Formula

C25H27ClFN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CCR1 antagonist 12 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCR1 antagonist 12921208-19-7CCRCC chemokine receptorEAE modelexperimental autoimmune encephalomyelitisarthritisrheumatoid arthritismultiple sclerosisTHP-1Inhibitorinhibitorinhibit

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