2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. FLT3 Reactive Oxygen Species Apoptosis
  4. FLT3-IN-29

FLT3-IN-29 (Compound MY-10) 是一种 FLT3 抑制剂 (对 FLT3-ITD 和 FLT3-D835Y 突变体的 IC50 分别为 6.5 和 10.3 nM)。FLT3-IN-29 可使细胞周期停滞在 G0/G1 期，并有效诱导细胞凋亡 (Apoptosis)。FLT3-IN-29 也可减少活性氧 (ROS) 和线粒体膜电位 (MMP)。FLT3-IN-29 具有抗白血病活性。

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FLT3-IN-29 Chemical Structure

FLT3-IN-29 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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3.  试用装只面向终端客户。

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FLT3-IN-29 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FLT3-IN-29 (Compound MY-10) is a FLT3 inhibitor (IC50s: 6.5 and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants). FLT3-IN-29 arrests cell cycle at the G0/G1 phase and efficiently induces Apoptosis. FLT3-IN-29 also reduces reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP). FLT3-IN-29 displays antileukemic activity[1].

体外研究
(In Vitro)

FLT3-IN-29 对 MV4-11 细胞具有良好的抗增殖活性 (IC50 = 0.59 μM)[1]。
FLT3-IN-29 (0.2-10 μM, 24 h) 可使细胞周期停滞在 G0/G1 期，诱导细胞凋亡，并降低 MV4-11 细胞中的 ROS 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FLT3-IN-29 相关抗体:
分子量

446.54

Formula

C25H30N6O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FLT3-IN-29 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3-IN-29FLT3Reactive Oxygen SpeciesApoptosisCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3AntiproliferativeMV4-11A549HCT116Antileukemic.Inhibitorinhibitorinhibit

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产品名称：
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目录号：
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