2. Gene
  3. CPLX2 - complexin 2 Gene

CPLX2 - complexin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：络合素 2

种属: Homo sapiens

同用名: CPX2; Hfb1; 921-L; CPX-2

基因 ID: 10814 | 基因类型: protein coding

关于 CPLX2

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:175,796,533-175,884,021 (from NCBI)

This gene has 10 transcripts (splice variants), 115 orthologues and 3 paralogues. Biased expression in brain (RPKM 63.0) and adrenal (RPKM 12.1).

功能概要

由复合蛋白/突触蛋白基因家族编码的蛋白质是在突触小泡胞吐作用中起作用的胞质蛋白。这些蛋白质结合 syntaxin，SNAP 受体的一部分。该基因的蛋白质产物与 SNAP 受体复合体结合并破坏它，从而允许递质释放。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2008 年 7 月]

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CPLX2 基因产物(2)

mRNA Protein Name
NM_001008220.2 NP_001008221.1 complexin-2
NM_006650.4 NP_006641.1 complexin-2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CPLX2 蛋白结构

Synaphin

Synaphin: Synaphin protein (1 - 134)

  • 0
  • 100
  • 134 a.a.
蛋白主名 其他名称

complexin-2

CPX II

重组 CPLX2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76282 CPLX2/Complexin-2 Protein, Human (His) Q6PUV4 (D2-K134) ≥95%

关联疾病

疾病名称 别名
Lacrimal Gland Carcinoma

Lacrimal Gland Cancer

Carcinoma Of The Lacrimal Gland

Malignant Neoplasm Of Lacrimal Gland

Malignant Tumour Of Lacrimal Gland

Neoplasm Of Lacrimal Gland

Tumor Of The Lacrimal Gland

Malignant Tumor Of Lacrimal Gland
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Epilepsy, Familial Temporal Lobe, 7

Familial Temporal Lobe Epilepsy 7

ETL7

Epilepsy, Temporal Lobe, Familial, Type 7
Lacrimal Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Lacrimal Gland
Lacrimal Gland Adenocarcinoma

Adenocarcinoma Of Lacrimal Gland
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03098 CPLX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CPLX2 VGNC VGNC:27652
Canis familiaris CPLX2 VGNC VGNC:39556
Mus musculus CPLX2 MGD MGI:104726
Rattus norvegicus CPLX2 RGD RGD:70945
Felis catus CPLX2 VGNC VGNC:102182
Others CPLX2 NCBI
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