2. Gene
  3. Wnk1 - WNK lysine deficient protein kinase 1 Gene

Wnk1 - WNK lysine deficient protein kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Hsn2; Prkwnk1

基因 ID: 116477 | 基因类型: protein coding

关于 Wnk1

功能概要

Enables several functions, including ATP binding activity; magnesium ion binding activity; and Potassium Channel Inhibitor activity. Involved in several processes, including cellular response to calcium ion; negative regulation of sodium ion transport; and protein autophosphorylation. Located in cytosol and membrane. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Wnk1 基因产物(3)

mRNA Protein Name
NM_001002823.2 NP_001002823.2 serine/threonine-protein kinase WNK1 isoform 1
NM_001199095.1 NP_001186024.1 serine/threonine-protein kinase WNK1 isoform 2
NM_053794.2 NP_446246.2 serine/threonine-protein kinase WNK1 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
10828064 RGD
enables magnesium ion binding IMP
IMP: 通过突变表型推断
10828064 RGD
enables molecular condensate scaffold activity IDA
IDA: 通过直接分析推断
36318922 RGD
enables potassium channel inhibitor activity IDA
IDA: 通过直接分析推断
16775035 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15350218 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
16083423 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10828064 RGD
enables protein serine/threonine kinase inhibitor activity IDA
IDA: 通过直接分析推断
15081430 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell volume homeostasis IDA
IDA: 通过直接分析推断
36318922 RGD
involved in cellular hyperosmotic response IDA
IDA: 通过直接分析推断
36318922 RGD
involved in cellular response to calcium ion IDA
IDA: 通过直接分析推断
24803536 RGD
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
10828064 RGD
involved in modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
26126716 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
26126716 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
26126716 RGD
involved in negative regulation of kinase activity IDA
IDA: 通过直接分析推断
15081430 RGD
involved in negative regulation of protein localization to plasma membrane IDA
IDA: 通过直接分析推断
17673510 RGD
involved in negative regulation of sodium ion transport IDA
IDA: 通过直接分析推断
16204408 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
10828064 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
10828064 RGD
involved in regulation of sodium ion transport IDA
IDA: 通过直接分析推断
16204408 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse EXP
EXP: 通过实验结果推断
26126716 RGD
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
26126716 RGD
is active in GABA-ergic synapse IMP
IMP: 通过突变表型推断
26126716 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
10828064 RGD
located in cytosol IDA
IDA: 通过直接分析推断
25515571 RGD
is active in intracellular non-membrane-bounded organelle IDA
IDA: 通过直接分析推断
36318922 RGD
located in membrane IDA
IDA: 通过直接分析推断
25515571 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine/threonine-protein kinase WNK1

protein kinase with no lysine 1

Wnk1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Wnk1 Q9JIH7 Syt2 Rattus norvegicus P29101
Anti Tag CoIP
15350218
种属内
Wnk1 Q9JIH7 Syt2 Rattus norvegicus P29101
Biochemical
15350218
种属内
Wnk1 Q9JIH7 Syt2 Rattus norvegicus P29101
Pull Down
15350218
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100626 WNK463 Inhibitor 99.75% 否
HY-112094 WNK-IN-11 Inhibitor 99.13% 否
HY-103100 SB-699551 Antagonist 99.53% 否
HY-151545 WNK1-IN-1 Inhibitor 99.40% 否
HY-112143 STOCK2S-26016 Inhibitor 98.7% 否
HY-101959A Tyrphostin 47 Inhibitor / 否
HY-RS15823 WNK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Wnk1 NCBI NCBI:65125
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