LRR1 - leucine rich repeat protein 1 Gene

中文名称：富亮氨酸重复蛋白 1

种属: Homo sapiens

同用名: LRR-1; PPIL5; 4-1BBLRR

关于 LRR1

功能概要

该基因编码的蛋白质含有富含亮氨酸的重复序列 (LRR) 。它与肿瘤坏死因子受体 (TNFR) 超家族的成员 TNFRSF9/4-1BB 特异性相互作用。该基因的过表达抑制了由 TNFRSF9 或 TNF 受体相关因子 2 (TRAF2) 诱导的 NF-kappa B 的激活，这表明该蛋白是 TNFRSF9 介导的信号级联的负调节因子。可变剪接导致多个转录变体。[RefSeq 提供，2011 年 2 月]

The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]