2. Gene
  3. Fas - Fas (TNF receptor superfamily member 6) Gene

Fas - Fas (TNF receptor superfamily member 6) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: lpr; APO1; APT1; CD95; TNFR6; Tnfrsf6

基因 ID: 14102 | 基因类型: protein coding

关于 Fas

功能概要

Enables identical protein binding activity. Involved in positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway; hematopoietic or lymphoid organ development; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; systemic lupus erythematosus; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic Cancer (multiple); pre-eclampsia (multiple); and urinary system Cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Apr 2022]

Fas 基因产物(2)

mRNA Protein Name
NM_001146708.1 NP_001140180.1 tumor necrosis factor receptor superfamily member 6 isoform 2 precursor
NM_007987.2 NP_032013.2 tumor necrosis factor receptor superfamily member 6 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
8524870 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7536190 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell mediated immunity IMP
IMP: 通过突变表型推断
18199416 MGI
acts upstream of or within T cell homeostasis IMP
IMP: 通过突变表型推断
8640868 MGI
acts upstream of or within activation-induced cell death of T cells IDA
IDA: 通过直接分析推断
12702495 MGI
acts upstream of or within activation-induced cell death of T cells IMP
IMP: 通过突变表型推断
7602121 MGI
acts upstream of or within apoptotic process IMP
IMP: 通过突变表型推断
8700551 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: 通过直接分析推断
7511063 MGI
acts upstream of or within cellular response to lithium ion IMP
IMP: 通过突变表型推断
20530871 MGI
involved in circadian rhythm IEP
IEP: 通过表达模式推断
23785138 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
17980593 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
12011074 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
13679421 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: 通过直接分析推断
8524870 MGI
involved in extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: 通过直接分析推断
10950869 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IGI
IGI: 通过遗传相互作用推断
12431371 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: 通过突变表型推断
8524870 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
7602121 MGI
acts upstream of or within hepatocyte apoptotic process IGI
IGI: 通过遗传相互作用推断
20436477 MGI
acts upstream of or within immunoglobulin production IMP
IMP: 通过突变表型推断
18199416 MGI
acts upstream of or within inflammatory cell apoptotic process IDA
IDA: 通过直接分析推断
12801066 MGI
acts upstream of or within inflammatory cell apoptotic process IMP
IMP: 通过突变表型推断
12801066 MGI
acts upstream of or within lymphocyte apoptotic process IDA
IDA: 通过直接分析推断
15632112 MGI
acts upstream of or within motor neuron apoptotic process IMP
IMP: 通过突变表型推断
13679421 MGI
acts upstream of or within necroptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
21052097 MGI
acts upstream of or within negative regulation of B cell activation IMP
IMP: 通过突变表型推断
6610701 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
7595210 MGI
acts upstream of or within negative thymic T cell selection IMP
IMP: 通过突变表型推断
10429671 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: 通过突变表型推断
20530871 MGI
involved in positive regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
10950869 MGI
acts upstream of or within regulation of B cell differentiation IMP
IMP: 通过突变表型推断
6610701 MGI
acts upstream of or within regulation of T cell differentiation IMP
IMP: 通过突变表型推断
6610701 MGI
acts upstream of or within regulation of hematopoietic progenitor cell differentiation IMP
IMP: 通过突变表型推断
9697835 MGI
acts upstream of or within regulation of myeloid cell differentiation IMP
IMP: 通过突变表型推断
9697835 MGI
acts upstream of or within response to glucocorticoid IMP
IMP: 通过突变表型推断
7602121 MGI
acts upstream of or within response to toxic substance IMP
IMP: 通过突变表型推断
8557033 MGI
acts upstream of or within spleen development IMP
IMP: 通过突变表型推断
18199416 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CD95 death-inducing signaling complex IDA
IDA: 通过直接分析推断
20935634 MGI
located in cell surface IDA
IDA: 通过直接分析推断
7595210 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
8788039 MGI
located in extracellular region IDA
IDA: 通过直接分析推断
7595210 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 6

FASLG receptor

Fas (TNF receptor superfamily member)

Fas antigen

apo-1 antigen

apoptosis-mediating surface antigen FAS

lymphoproliferation

重组 Fas 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70330 Fas/CD95 Protein, Mouse (HEK293, His) P25446 (Q22-R169) ≥95%
HY-P78296 Fas/CD95 Protein, Mouse (HEK293, Fc) P25446 (Q22-R169) ≥95%

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-16046 Rimiducid 99.81% Phase 3
HY-13721 Phenoxodiol 99.76% Phase 3
Pre-clinical Phase
生物活性分子 (32)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12325 GSK2194069 Inhibitor 99.84% 否
HY-14414 GSK4112 Inhibitor 99.87% 否
HY-133897 (Rac)-Indoximod 98.13% 否
HY-150190 F5446 99.38% 否
HY-100755 KR-33493 Inhibitor 99.75% 否
HY-103243 TCPOBOP Inhibitor 98.67% 否
HY-16100 BI 99179 Inhibitor 99.38% 否
HY-101849 Fasentin ≥98.0% 否
HY-N0704 Agrimol B 99.75% 否
HY-N0686 Pseudoprotodioscin Inhibitor 98.76% 否
HY-P10102 Kp7-6 Inhibitor 99.77% 否
HY-Y0598 trans-Chalcone 98.65% 否
HY-103348 Boc-Asp(OMe)-fluoromethyl ketone Inhibitor ≥98.0% 否
HY-112716 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride Inhibitor ≥99.0% 否
HY-129624A Bisindolylmaleimide VIII acetate 99.68% 否
HY-N6777 Penicillic acid Inhibitor 99.83% 否
HY-108610A Edelfosine Inducer ≥98.0% 否
HY-103347 M50054 Inhibitor 98.44% 否
HY-N7930 Crenulatin ≥99.0% 否
HY-E70404 FastTaq DNA Polymerase(5'→3' exo-) / 否
HY-103323 Fas C-Terminal Tripeptide Inhibitor / 否
HY-113963 Ac-​IETD-​CHO Inhibitor / 否
HY-146197 Apoptotic agent-1 Inducer / 否
HY-167879 (Rac)-NPD6433 Inhibitor / 否
HY-P3779 Amyloid 17-42 Inducer / 否
HY-P5798 Fasciculin-I Inhibitor / 否
HY-RS04751 FAS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-118147 ML356 Inhibitor / 否
HY-129624 Bisindolylmaleimide VIII / 否
HY-167879A NPD6433 Inhibitor / 否
HY-P10401 TAT-GluR6-9c Antagonist / 否
HY-P5797 Fasciculin-II Inhibitor / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99133 Anti-Mouse Fas Ligand Antibody (MFL3) Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fas NCBI NCBI:355
Macaca fascicularis Fas NCBI NCBI:102140989
Rattus norvegicus Fas NCBI NCBI:246097
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