2. Gene
  3. Gcgr - glucagon receptor Gene

Gcgr - glucagon receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：胰高血糖素受体

种属: Mus musculus

同用名: GR

基因 ID: 14527 | 基因类型: protein coding

关于 Gcgr

Chromosome 11: 120,421,525-120,429,812 forward strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 184 orthologues, 41 paralogues and is associated with 63 phenotypes. Biased expression in liver adult (RPKM 145.3), liver E18 (RPKM 21.1) and 4 other tissues.

功能概要

该基因编码的蛋白可启动胰高血糖素受体活性。参与多个过程，包括细胞对胰高血糖素刺激的反应；葡萄糖稳态；和糖原代谢过程的调节。在细胞对饥饿和基因表达的正调控反应的上游或内部起作用。预计位于核内体。预计是质膜的组成部分。预计在质膜上有活性。以多种结构表达，包括大脑；脚间充质；直觉;肝;和雄性生殖腺或器官。该基因的人类直系同源物与 Mahvash 病和 2 型糖尿病有关。与人类 GCGR（胰高血糖素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Glucagon Receptor activity. Involved in several processes, including cellular response to glucagon stimulus; glucose homeostasis; and regulation of glycogen metabolic process. Acts upstream of or within cellular response to starvation and positive regulation of gene expression. Predicted to be located in endosome. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; foot mesenchyme; gut; liver; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (Glucagon Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Gcgr 基因产物(1)

mRNA Protein Name
NM_008101.2 NP_032127.2 glucagon receptor precursor

Gcgr 蛋白结构

HRM

HRM: pfam02793 (55 - 124)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (136 - 416)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (140 - 165)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (174 - 196)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (225 - 252)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (264 - 284)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (300 - 329)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (345 - 370)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (379 - 404)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
蛋白主名 其他名称

glucagon receptor

GL-R

相关产品

Approval
生物活性分子 (9)
目录号 产品名 作用方式
纯度 是否罕见病
HY-114118 Semaglutide Agonist 99.84% 否
HY-13443 Exendin-4 Agonist 99.94% 是
HY-P0014 Liraglutide Agonist 99.85% 否
HY-P0082 Glucagon (1-29), bovine, human 99.84% 否
HY-114118A Semaglutide TFA Agonist 99.92% 否
HY-P0119 Lixisenatide Agonist 99.93% 否
HY-P0120 Dulaglutide Agonist 90.00% 否
HY-P0119A Lixisenatide acetate Agonist 99.65% 否
HY-114118B Semaglutide acetate Agonist 99.59% 否
Clinical Phase
生物活性分子 (27)
目录号 产品名 作用方式
纯度 Phase
HY-13443A Exendin-4 acetate Agonist 99.67% Phase 4
HY-P3463 Beinaglutide 99.74% Phase 4
HY-P3506 Retatrutide Agonist 99.95% Phase 3
HY-112185 Orforglipron Agonist 99.80% Phase 3
HY-P3375 Mazdutide Agonist 99.74% Phase 3
HY-P3506A Retatrutide TFA Agonist 99.31% Phase 3
HY-P2221B Glepaglutide acetate Agonist 99.92% Phase 3
HY-P0165 Taspoglutide Agonist 99.51% Phase 3
HY-P3366 Ecnoglutide Agonist 98.61% Phase 3
HY-P2221 Glepaglutide Agonist / Phase 3
HY-P3375A Mazdutide TFA Agonist / Phase 3
HY-P3506B Retatrutide acetate Agonist / Phase 3
HY-125824 Danuglipron Agonist 98.63% Phase 2
HY-50663 MK 0893 Antagonist 99.86% Phase 2
HY-P4146 Survodutide Agonist 99.98% Phase 2
HY-19904 Adomeglivant Antagonist 99.63% Phase 2
HY-P2231A Cotadutide acetate Agonist 98.88% Phase 2
HY-19947 PF-06291874 Antagonist 99.18% Phase 2
HY-P3291 Dapiglutide Agonist 99.40% Phase 2
HY-12525 LGD-6972 Antagonist ≥98.0% Phase 2
HY-P4146A Survodutide TFA Agonist 99.62% Phase 2
HY-P2231 Cotadutide Agonist 98.88% Phase 2
HY-P10018 Bamadutide Agonist 99.96% Phase 2
HY-P10019 Pegsebrenatide Agonist / Phase 2
HY-P3498 Elsiglutide Agonist / Phase 2
HY-P10031 SAR441255 Agonist / Phase 1
HY-19374 BAY-27-9955 Antagonist / Phase 1
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99383 Volagidemab Antagonist 98.43% Phase 2
HY-P99357 Crotedumab Inhibitor 96.61% Phase 1
Pre-clinical Phase
生物活性分子 (102)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P0055 GLP-1(7-37) 99.82% 否
HY-P0054 GLP-1(7-36), amide acetate 99.36% 否
HY-103546 BETP Agonist 99.35% 否
HY-121835 GLP-1R agonist 2 Agonist 99.94% 否
HY-101116 GLP-1R Antagonist 1 Antagonist 99.84% 否
HY-P0055A GLP-1(7-37) acetate 99.63% 否
HY-P1141 GLP-1(9-36)amide Antagonist 99.78% 否
HY-P1024 GLP-2(1-33)(human) Agonist 98.73% 否
HY-153865 Lotiglipron Agonist 99.68% 否
HY-124622 NNC-0640 Modulator 98.43% 否
HY-P1144 Oxyntomodulin (bovine, porcine) Agonist 99.91% 否
HY-P0054B GLP-1(7-36), amide TFA 98.66% 否
HY-142162 LSN3318839 Modulator 99.81% 否
HY-129658A TT-OAD2 Agonist 99.77% 否
HY-103547 L-168049 Antagonist 99.93% 否
HY-P1348 GLP-1 moiety from Dulaglutide 99.91% 否
HY-112679 GLP-1 receptor agonist 2 Agonist 98.70% 否
HY-N0630 Shanzhiside methyl ester Agonist 99.71% 否
HY-50159 Glucagon receptor antagonists-3 Antagonist 98.52% 否
HY-50158 Glucagon receptor antagonists-2 Antagonist 99.23% 否
HY-P1145A Glucagon-like peptide 1 (1-37), human TFA Agonist 98.09% 否
HY-141839 GLP-1R modulator C16 Modulator 99.60% 否
HY-P2625 GLP-2(3-33) Agonist 98.03% 否
HY-116819A VU0453379 hydrochloride Modulator ≥99.0% 否
HY-P1160 Bay 55-9837 Agonist 99.08% 否
HY-141842 GLP-1R modulator L7-028 Modulator 98.77% 否
HY-P3102 GLP-1(32-36)amide 98.42% 否
HY-P3101 GLP-1(28-36)amide 98.64% 否
HY-P1143A [Des-His1,Glu9]-Glucagon amide TFA Antagonist 99.62% 否
HY-141840 GLP-1R modulator C5 Modulator 99.60% 否
HY-P10032A NN1177 TFA Agonist 98.66% 否
HY-50675 GRA Ex-25 Inhibitor 98.59% 否
HY-144035 GLP-1R agonist 4 Agonist 99.77% 否
HY-P0150 Glucagon (19-29), human Inhibitor 99.11% 否
HY-148212 GLP-1R agonist 17 Agonist / 否
HY-144034 GLP-1R agonist 3 Agonist 99.15% 否
HY-116854 NNC 92-1687 Antagonist 98.74% 否
HY-148844 GCGR antagonist 2 Antagonist 99.76% 否
HY-P1141A GLP-1(9-36)amide TFA Antagonist 98.00% 否
HY-112185A Orforglipron hemicalcium hydrate Agonist 99.48% 否
HY-114118F Semaglutide, FITC labeled Agonist 95.51% 否
HY-145412 GLP-1 receptor agonist 7 98.41% 否
HY-116819 VU0453379 Modulator ≥98.0% 否
HY-10036 Glucagon receptor antagonists-1 Antagonist 98.65% 否
HY-P3622 (Ser8)-GLP-1 (7-36) amide, human Agonist 99.10% 否
HY-P1228 HAEGTFT 98.81% 否
HY-119739 Skyrin Antagonist 97.0% 否
HY-P5815A GLP-1 (1-36) amide (human, rat) (TFA) 98.81% 否
HY-P1225 {Val1}-Exendin-3/4 99.45% 否
HY-147622 GLP-1R agonist 9 Agonist / 否
HY-P1231 GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 99.03% 否
HY-P1226 HAEGTFTSD Agonist 98.48% 否
HY-P0054A GLP-1(7-36), amide Agonist 99.31% 否
HY-P2497 Exendin (5-39) Antagonist 99.81% 否
HY-N2452 Cochinchinenin C Agonist / 否
HY-P1229 FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 98.01% 否
HY-P1223 Exendin-3/4 (59-86) 98.19% 否
HY-124803 GPCR modulator-1 Modulator / 否
HY-P1224 HAEGTFTSDVS 98.62% 否
HY-145458 GLP-1 receptor agonist 9 Agonist / 否
HY-138996 GLP-1 receptor agonist 8 Agonist / 否
HY-129658 TT-OAD2 free base Agonist / 否
HY-128781 Glucagon receptor antagonists-5 Antagonist / 否
HY-159696A ISIS 449884 sodium Inhibitor / 否
HY-P5815 GLP-1 (1-36) amide (human, rat) / 否
HY-153476 GIP/GLP-1 dual receptor agonist-1 Agonist / 否
HY-144133 GLP-1R agonist 5 Agonist / 否
HY-P3539 Exendin-4 (3-39) / 否
HY-P10032 NN1177 Agonist / 否
HY-P3616 Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide / 否
HY-159696 ISIS 449884 Inhibitor / 否
HY-144134 GLP-1R agonist 6 Agonist / 否
HY-144135 GLP-1R agonist 7 Agonist / 否
HY-129657 GLP-1 receptor agonist 4 Agonist / 否
HY-107129 MK-3577 Antagonist / 否
HY-129656 GLP-1 receptor agonist 3 Agonist / 否
HY-P1143 [Des-His1,Glu9]-Glucagon amide Antagonist / 否
HY-P4672 (Met(O)27)-Glucagon (1-29) (human, rat, porcine) / 否
HY-144136 GLP-1R agonist 8 Agonist / 否
HY-P5578 A8SGLP-1 Agonist / 否
HY-P3621 Biotinyl-Glucagon (1-29), human, bovine, porcine / 否
HY-P0212A Neuropeptide Y, porcine TFA / 否
HY-P10341 ZP3022 Agonist / 否
HY-P3608 [Des-His1,Glu9] Glucagon Antagonist / 否
HY-P3102A GLP-1(32-36)amide TFA / 否
HY-P10736 AMG133 peptide payload / 否
HY-P3101A GLP-1(28-36)amide TFA / 否
HY-P5074 GRPP (human) Agonist / 否
HY-P5578A A8SGLP-1 TFA Agonist / 否
HY-P3542 Des His1, Glu8 Exendin-4 Antagonist / 否
HY-P3388 Utreglutide Agonist 98.42% 否
HY-P1160A Bay 55-9837 TFA / 否
HY-P10337 OXM-7 Agonist / 否
HY-P0082A Glucagon (1-29), bovine, human hydrochloride / 否
HY-P5161A FC382K10W15 TFA Agonist / 否
HY-144033 GLP-1R agonist 1 Agonist / 否
HY-P1144A Oxyntomodulin (bovine, porcine) (TFA) Agonist / 否
HY-P0212 Neuropeptide Y, porcine Agonist / 否
HY-125824A Danuglipron tromethamine Agonist / 否
HY-12525A LGD-6972 sodium Antagonist / 否
HY-12735 SCH 900822 Antagonist / 否
HY-P1145 Glucagon-like peptide 1 (1-37), human Agonist / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990013 Gulgafafusp alfa Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gcgr NCBI NCBI:2642
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