1. Gene
  2. RNF38 - ring finger protein 38 Gene

RNF38 - ring finger protein 38 Gene

中文名称:无名指蛋白 38

种属: Homo sapiens

基因 ID: 152006 | 基因类型: protein coding

关于 RNF38

Cytogenetic location: 9p13.2 Genomic coordinates (GRCh38): 9:36,336,400-36,487,669 (from NCBI)

This gene has 10 transcripts (splice variants), 267 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 25.8), ovary (RPKM 14.9) and 25 other tissues.

功能概要

该基因编码的蛋白质在其羧基末端具有卷曲螺旋基序和 RING-H2 基序 (C3H2C2) 。 RING 基序是一个锌结合结构域,存在于大量蛋白质中,在多种细胞过程中发挥作用,包括肿瘤发生、发育、信号转导和细胞凋亡。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2008 年 12 月]

This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and Apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

RNF38 基因产物(5)

mRNA Protein Name
NM_022781.5 NP_073618.3 E3 ubiquitin-protein ligase RNF38 isoform 1
NM_194328.3 NP_919309.1 E3 ubiquitin-protein ligase RNF38 isoform 2
NM_194329.3 NP_919310.1 E3 ubiquitin-protein ligase RNF38 isoform 3
NM_194330.3 NP_919311.1 E3 ubiquitin-protein ligase RNF38 isoform 2
NM_194332.3 NP_919313.1 E3 ubiquitin-protein ligase RNF38 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
23973461 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
23973461 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
23973461 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RNF38 蛋白结构

zf-RING_2

zf-RING_2: Ring finger domain (463 - 504)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 515 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF38

RING-type E3 ubiquitin transferase RNF38

RNF38 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RNF38 Q9H0F5 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
种属内
RNF38 Q9H0F5 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
种属内
RNF38 Q9H0F5 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
种属内
RNF38 Q9H0F5 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
种属内
RNF38 Q9H0F5 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 KPRP Homo sapiens Q5T749
Y2H Array
32296183
种属内
RNF38 Q9H0F5 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
种属内
RNF38 Q9H0F5 OXER1 Homo sapiens Q8TDS5
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 OXER1 Homo sapiens Q8TDS5
Y2H Array
32296183
种属内
RNF38 Q9H0F5 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Array
32296183
种属内
RNF38 Q9H0F5 KRTAP21-2 Homo sapiens Q3LI59
Y2H Array
32296183
种属内
RNF38 Q9H0F5 KRTAP21-2 Homo sapiens Q3LI59
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
RNF38 Q9H0F5 RNF208 Homo sapiens Q9H0X6
Validated Y2H
32296183
种属内
RNF38 Q9H0F5 RNF208 Homo sapiens Q9H0X6
Y2H Array
32296183
种属内
RNF38 Q9H0F5 RNF208 Homo sapiens Q9H0X6
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
种属内
RNF38 Q9H0F5 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colon Mucinous Adenocarcinoma

Colonic Mucinous Adenocarcinoma

Mucinous Adenocarcinoma Of The Colon

Uterine Corpus Endometrial Carcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus RNF38 VGNC VGNC:34064
Mus musculus RNF38 MGD MGI:1920719
Felis catus RNF38 VGNC VGNC:64701
Macaca mulatta RNF38 VGNC VGNC:76761
Rattus norvegicus RNF38 RGD RGD:621856
Canis familiaris RNF38 VGNC VGNC:45668