DBI - diazepam binding inhibitor, acyl-CoA binding protein Gene

中文名称：地西泮结合抑制因子，酰基辅酶 A 结合蛋白

种属: Homo sapiens

同用名: EP; ACBP; ACBD1; CCK-RP

关于 DBI

功能概要

该基因编码地西泮结合抑制剂，这是一种受激素调节的蛋白质，参与脂质代谢和 β-咔啉类和苯二氮卓类药物的置换，后者调节位于脑突触中的 A 型γ-氨基丁酸受体的信号转导。该蛋白质从酵母到哺乳动物都是保守的，具有最高保守性的结构域由七个连续残基组成，这些残基构成中链和长链酰基辅酶 A 酯的疏水结合位点。除了作为促肾上腺皮质激素依赖性肾上腺类固醇生成的介质外，地西泮结合抑制剂还已知可介导胰腺分泌的反馈调节和胆囊收缩素的餐后释放。已鉴定出位于 6、8 和 16 号染色体上的三个假基因。已针对该基因描述了编码不同亚型的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes diazepam binding inhibitor, a protein that is regulated by Hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]