1. Gene
  2. Ntrk3 - neurotrophic tyrosine kinase, receptor, type 3 Gene

Ntrk3 - neurotrophic tyrosine kinase, receptor, type 3 Gene

中文名称:神经营养性酪氨酸激酶受体 3 型

种属: Mus musculus

同用名: TrkC; Ntrk3_tv3

基因 ID: 18213 | 基因类型: protein coding

关于 Ntrk3

Chromosome 7: 77,825,707-78,387,760 reverse strand.GRCm39:CM001000.3

This gene has 20 transcripts (splice variants), 271 orthologues, 53 paralogues and is associated with 41 phenotypes. Broad expression in cerebellum adult (RPKM 7.6), CNS E18 (RPKM 6.3) and 16 other tissues.

功能概要

预计该基因编码的蛋白具有多种功能,包括 GPI 相关肝配蛋白受体活性;神经营养蛋白结合活性;和 p53 结合活性。作用于多个过程的上游或内部,包括晶状体纤维细胞分化;神经发生;和神经元动作电位传播。位于细胞质中。以多种结构表达,包括消化系统;心血管系统;中枢神经系统;泌尿生殖系统;和周围神经系统。该基因的人类直系同源物与腺样囊性癌有关;结直肠癌;和胃癌。与人类 NTRK3(神经营养受体酪氨酸激酶 3)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including GPI-linked Ephrin Receptor activity; neurotrophin binding activity; and p53 binding activity. Acts upstream of or within several processes, including lens fiber cell differentiation; neurogenesis; and neuronal action potential propagation. Located in cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and peripheral nervous system. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach Cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk3 基因产物(2)

mRNA Protein Name
NM_008746.5 NP_032772.3 NT-3 growth factor receptor isoform a precursor
NM_182809.2 NP_877961.1 NT-3 growth factor receptor isoform b precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11684666 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10207144 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ntrk3 蛋白结构

LRR_8

LRR_8: pfam13855 (102 - 159)

LRR_1

LRR_1: sd00031 (104 - 127)

LRR_1

LRR_1: sd00031 (128 - 150)

LRR_1

LRR_1: sd00031 (151 - 163)

TPKR_C2

TPKR_C2: pfam16920 (162 - 207)

ig

ig: pfam00047 (213 - 298)

Ig

Ig: cd00096 (226 - 230)

Ig

Ig: cd00096 (239 - 243)

Ig

Ig: cd00096 (265 - 269)

Ig

Ig: cd00096 (280 - 285)

Ig

Ig: cd00096 (293 - 296)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (303 - 395)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (304 - 310)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (312 - 315)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (318 - 326)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (329 - 336)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (339 - 342)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (347 - 353)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (357 - 365)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (373 - 381)

IgI_TrKABC_d5

IgI_TrKABC_d5: cd04971 (384 - 392)

PTKc_TrkC

PTKc_TrkC: cd05094 (531 - 817)

  • 0
  • 200
  • 400
  • 600
  • 825 a.a.
蛋白主名 其他名称

NT-3 growth factor receptor

GP145-TrkC

neurotrophin-3

trk-C

trkC tyrosine kinase

重组 Ntrk3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71386 TrkC Protein, Mouse (HEK293, His) Q6VNS1 (C32-T429) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ntrk3 NCBI NCBI:4916