Pik3cd - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Gene

中文名称：磷脂酰肌醇 4 ,5-二磷酸 3-激酶催化亚基 δ

种属: Mus musculus

同用名: p110delta; 2410099E07Rik; 2610208K16Rik

关于 Pik3cd

功能概要

预测该基因编码的蛋白具有 1-磷脂酰肌醇 3-激酶活性和 1-磷脂酰肌醇 4-磷酸 3-激酶活性。参与血管生成的正向调节和蛋白激酶 B 信号的正向调节。作用于多个过程的上游或内部，包括 B 细胞激活； B 细胞稳态；和对真菌的防御反应。预测位于胞质溶胶中。预计是磷脂酰肌醇 3-激酶复合物的一部分。预计在细胞质和质膜中有活性。在早期胚胎中表达；淋巴系统；神经系统;感觉器官；和睾丸。该基因的人类直系同源物与结直肠癌有关；子宫内膜癌;和免疫缺陷 14. 与人 PIK3CD（磷脂酰肌醇 4,5-二磷酸 3-激酶催化亚基三角洲）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in positive regulation of angiogenesis and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including B cell activation; B cell homeostasis; and defense response to fungus. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in early embryo; hemolymphoid system; nervous system; sensory organ; and testis. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and immunodeficiency 14. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Apr 2022]