2. Gene
  3. Sirt7 - sirtuin 7 Gene

Sirt7 - sirtuin 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：沉默信息调节因子 2 相关酶类 7

种属: Mus musculus

基因 ID: 209011 | 基因类型: protein coding

关于 Sirt7

Chromosome 11: 120,509,198-120,516,066 reverse strand.GRCm39:CM001004.3

This gene has 11 transcripts (splice variants), 189 orthologues, 6 paralogues and is associated with 33 phenotypes. Ubiquitous expression in spleen adult (RPKM 45.7), thymus adult (RPKM 44.) and 28 other tissues.

功能概要

该基因编码的蛋白可启动 NAD 依赖性组蛋白脱乙酰酶活性（H3-K18 特异性）和蛋白质丙酰赖氨酸脱丙酰酶活性。参与多个过程，包括减数分裂时的同源染色体配对；蛋白质脱酰；通过非同源末端连接调节双链断裂修复。位于染色质和双链断裂位点。以多种结构表达，包括第 1 鳃弓上颌骨成分；中枢神经系统;眼睛;性腺;和脾脏。与人类 SIRT7（sirtuin 7）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables NAD-dependent histone deacetylase activity (H3-K18 specific) and protein-propionyllysine depropionylase activity. Involved in several processes, including homologous chromosome pairing at meiosis; protein deacylation; and regulation of double-strand break repair via nonhomologous end joining. Located in chromatin and site of double-strand break. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; eye; gonad; and spleen. Orthologous to human SIRT7 (Sirtuin 7). [provided by Alliance of Genome Resources, Apr 2022]

Sirt7 基因产物(2)

mRNA Protein Name
NM_153056.3 NP_694696.2 NAD-dependent protein deacetylase sirtuin-7 isoform 1
NM_001363439.1 NP_001350368.1 NAD-dependent protein deacetylase sirtuin-7 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD-dependent histone H3K18 deacetylase activity IMP
IMP: 通过突变表型推断
27225932 MGI
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
25200183 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
25200183 MGI
enables protein-propionyllysine depropionylase activity IDA
IDA: 通过直接分析推断
30026585 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA repair-dependent chromatin remodeling IMP
IMP: 通过突变表型推断
27225932 MGI
involved in homologous chromosome pairing at meiosis IMP
IMP: 通过突变表型推断
31256246 MGI
involved in negative regulation of gene expression, epigenetic IMP
IMP: 通过突变表型推断
31226208 MGI
involved in osteoblast differentiation IMP
IMP: 通过突变表型推断
30026585 MGI
involved in protein deacetylation IDA
IDA: 通过直接分析推断
25200183 MGI
involved in protein depropionylation IDA
IDA: 通过直接分析推断
30026585 MGI
involved in regulation of mitochondrion organization IMP
IMP: 通过突变表型推断
25200183 MGI
involved in regulation of protein export from nucleus IMP
IMP: 通过突变表型推断
31075303 MGI
involved in retrotransposon silencing IMP
IMP: 通过突变表型推断
31226208 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
31226208 MGI
located in site of double-strand break IMP
IMP: 通过突变表型推断
27225932 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Sirt7 蛋白结构

Smc

Smc: cl34174 (7 - 100)

SIRT7

SIRT7: cd01410 (101 - 314)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
蛋白主名 其他名称

NAD-dependent protein deacetylase sirtuin-7

NAD-dependent deacetylase sirtuin-7

NAD-dependent protein deacylase sirtuin-7

SIR2-like protein 7

regulatory protein SIR2 homolog 7

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135899 SIRT7 inhibitor 97491 Inhibitor 98.03% 否
HY-159124 YZL-51N Inhibitor / 否
HY-150727 SIRT5 inhibitor 4 Inhibitor / 否
HY-156489 Epigenetic factor-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sirt7 NCBI NCBI:51547
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