2. Gene
  3. ERP44 - endoplasmic reticulum protein 44 Gene

ERP44 - endoplasmic reticulum protein 44 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：内质网蛋白 44

种属: Homo sapiens

同用名: PDIA10; TXNDC4

基因 ID: 23071 | 基因类型: protein coding

关于 ERP44

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:99,979,185-100,099,000 (from NCBI)

This gene has 15 transcripts (splice variants), 208 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 19.6), placenta (RPKM 16.9) and 25 other tissues.

功能概要

该基因编码内质网 (ER) 蛋白的蛋白质二硫键异构酶 (PDI) 家族的成员。它具有一个推断的 N 末端信号肽、一个具有催化活性的硫氧还蛋白 (TRX) 结构域、两个 TRX 样结构域和一个 C 末端 ER 保留序列。这种蛋白质作为分泌途径的 pH 调节伴侣，可能在内质网 - 高尔基体界面的蛋白质质量控制中发挥作用。[RefSeq 提供，2016 年 12 月]

This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]

ERP44 基因产物(1)

mRNA Protein Name
NM_015051.3 NP_055866.1 endoplasmic reticulum resident protein 44 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17805346 GOA
enables protein disulfide isomerase activity IDA
IDA: 通过直接分析推断
11847130 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glycoprotein metabolic process IDA
IDA: 通过直接分析推断
11847130 GOA
involved in protein folding IDA
IDA: 通过直接分析推断
11847130 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
11847130 GOA
involved in response to unfolded protein IDA
IDA: 通过直接分析推断
11847130 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19995400 GOA
located in endoplasmic reticulum lumen IDA
IDA: 通过直接分析推断
11847130 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
11847130 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: 通过直接分析推断
15308636 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ERP44 蛋白结构

Thioredoxin

Thioredoxin: Thioredoxin (32 - 138)

Thioredoxin_6

Thioredoxin_6: Thioredoxin-like domain (167 - 350)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
蛋白主名 其他名称

endoplasmic reticulum resident protein 44

ER protein 44

重组 ERP44 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70901 TXNDC4 Protein, Human (HEK293, His) Q9BS26 (E30-D402) ≥95%

关联疾病

疾病名称 别名
Multiple Sulfatase Deficiency

Mucosulfatidosis

MSD

Sulfatidosis, Juvenile, Austin Type

Multiple Sulfatase Deficiency Disease

Juvenile Sulfatidosis, Austin Type

Juvenile Sulfatidosis

Sulfatidosis Juvenile, Austin Type

Austin Syndrome

Sulfatidosis Juvenile Austin Type

Sulfatase Deficiency, Multiple
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04515 ERP44 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ERP44 MGD MGI:1923549
Macaca mulatta ERP44 VGNC VGNC:72295
Bos taurus ERP44 VGNC VGNC:28597
Felis catus ERP44 VGNC VGNC:61957
Canis familiaris ERP44 VGNC VGNC:51716
Rattus norvegicus ERP44 RGD RGD:1309176
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