FMO2 - flavin containing dimethylaniline monoxygenase 2 Gene

中文名称：含黄素二甲基苯胺单加氧酶 2

种属: Homo sapiens

同用名: FMO1B1

关于 FMO2

功能概要

该基因编码含黄素的单加氧酶家族成员。它是一种 NADPH 依赖性酶，可通过 N-羟胺中间体催化某些伯烷基胺的 N-氧化。然而，某些人群中含有一个等位基因 (FMO2*2A) ，该等位基因带有过早终止密码子，导致蛋白质 C 末端被截短，没有催化活性，并且可能会迅速降解。该基因与其他相关家族成员位于 1 号染色体上的簇中。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 8 月]

This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent Enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]