FMO4 - flavin containing dimethylaniline monoxygenase 4 Gene

中文名称：含黄素的二甲基苯胺单加氧酶 4

种属: Homo sapiens

同用名: FMO2

关于 FMO4

功能概要

饮食来源的氨基三甲胺 (TMA) 的代谢 N-氧化由含黄素的单加氧酶介导，并受人类遗传性 FMO3 多态性的影响。这导致 TMA N-氧化能力降低的小亚群，并导致鱼腥味综合症 (三甲基胺尿症) 。三种形式的酶由聚集在 1q23-q25 区域的基因编码。含黄素的单加氧酶是 NADPH 依赖性黄素酶，可催化药物、杀虫剂和异生素中软亲核杂原子中心的氧化。[RefSeq 提供，2015 年 1 月]

Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the Enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]