FMO5 - flavin containing dimethylaniline monoxygenase 5 Gene

中文名称：含黄素二甲基苯胺单加氧酶 5

种属: Homo sapiens

同用名: hBVMO1

关于 FMO5

功能概要

饮食来源的氨基三甲胺 (TMA) 的代谢 N-氧化由含黄素的单加氧酶介导，并受人类遗传性 FMO3 多态性的影响，导致 TMA N-氧化能力降低的小亚群导致鱼腥味综合征三甲基氨基尿症.这种酶的三种形式，即在胎儿肝脏中发现的 FMO1、在成人肝脏中发现的 FMO2 和 FMO3，由聚集在 1q23-q25 区域的基因编码。含黄素的单加氧酶是 NADPH 依赖性黄素酶，可催化药物、杀虫剂和异生素中软亲核杂原子中心的氧化。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 1 月]

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the Enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]