LARP1 - La ribonucleoprotein 1, translational regulator Gene

中文名称：La 核糖核蛋白 1，翻译调节器

种属: Homo sapiens

同用名: LARP; Lar1; Lhp1

基因 ID: 23367 | 基因类型: protein coding

关于 LARP1

Cytogenetic location: 5q33.2 Genomic coordinates (GRCh38): 5:154,682,979-154,817,605 (from NCBI)

This gene has 20 transcripts (splice variants), 208 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 29.3), brain (RPKM 25.2) and 25 other tissues.

功能概要

启用真核起始因子 4E 结合活性；核酸结合活性；和核糖体小亚基结合活性。涉及多个过程，包括 TORC1 信号；细胞对雷帕霉素的反应；和基因表达的转录后调控。位于细胞质应激颗粒中。与 TORC1 复合物和多核糖体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Involved in several processes, including TORC1 signaling; cellular response to rapamycin; and posttranscriptional regulation of gene expression. Located in cytoplasmic stress granule. Colocalizes with TORC1 complex and polysomal ribosome. [provided by Alliance of Genome Resources, Apr 2022]

LARP1 基因产物(9)

mRNA	Protein	Name
NM_001367713.1	NP_001354642.1	la-related protein 1 isoform 3
NM_001367714.1	NP_001354643.1	la-related protein 1 isoform 3
NM_001367715.1	NP_001354644.1	la-related protein 1 isoform 4
NM_001367716.1	NP_001354645.1	la-related protein 1 isoform 5
NM_001367717.1	NP_001354646.1	la-related protein 1 isoform 6
NM_001367718.1	NP_001354647.1	la-related protein 1 isoform 7
NM_001367719.1	NP_001354648.1	la-related protein 1 isoform 3
NM_015315.6	NP_056130.2	la-related protein 1 isoform 1
NM_033551.3	NP_291029.2	la-related protein 1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA 7-methylguanosine cap binding	IDA IDA: 通过直接分析推断	28379136	GOA
enables RNA cap binding	IDA IDA: 通过直接分析推断	24532714	GOA
enables eukaryotic initiation factor 4E binding	IPI IPI: 通过物理相互作用推断	20430826	GOA
enables mRNA 3'-UTR binding	IDA IDA: 通过直接分析推断	23711370	GOA
enables mRNA 5'-UTR binding	IDA IDA: 通过直接分析推断	24532714	GOA
enables mRNA 5'-UTR binding	IMP IMP: 通过突变表型推断	25940091	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15161933	GOA
enables ribosomal small subunit binding	IDA IDA: 通过直接分析推断	28673543	GOA
enables translation activator activity	IMP IMP: 通过突变表型推断	24532714	GOA
enables translation initiation factor binding	IDA IDA: 通过直接分析推断	24532714	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in TOR signaling	IMP IMP: 通过突变表型推断	24532714	GOA
involved in TORC1 signaling	IMP IMP: 通过突变表型推断	25940091	GOA
involved in cell population proliferation	IMP IMP: 通过突变表型推断	24532714	GOA
involved in cellular response to rapamycin	IMP IMP: 通过突变表型推断	25940091	GOA
involved in mRNA stabilization	IMP IMP: 通过突变表型推断	25940091	GOA
involved in negative regulation of translation	IMP IMP: 通过突变表型推断	25940091	GOA
involved in negative regulation of translational initiation	IMP IMP: 通过突变表型推断	28379136	GOA
involved in positive regulation of macroautophagy	IMP IMP: 通过突变表型推断	22354037	GOA
involved in positive regulation of translational initiation	IMP IMP: 通过突变表型推断	29244122	GOA
involved in positive regulation of viral genome replication	IMP IMP: 通过突变表型推断	26735137	GOA
involved in post-transcriptional regulation of gene expression	IDA IDA: 通过直接分析推断	26001795	GOA
involved in response to amino acid starvation	IMP IMP: 通过突变表型推断	25940091	GOA
involved in translational initiation	IMP IMP: 通过突变表型推断	20430826	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of TORC1 complex	IDA IDA: 通过直接分析推断	24532714	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	20430826	GOA
located in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	25940091	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LARP1 蛋白结构

0
200
400
600
800
1019 a.a.

蛋白主名

其他名称

la-related protein 1

La ribonucleoprotein domain family member 1

LARP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LARP1	Q6PKG0	YWHAZ	Homo sapiens	P63104	CoIP	15324660
种属内	LARP1	Q6PKG0	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
种属内	LARP1	Q6PKG0	YWHAE	Homo sapiens	P62258	Crosslink	36931259

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07526	LARP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07527	LARP1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	LARP1	RGD	RGD:1306683
Mus musculus	LARP1	MGD	MGI:1890165
Felis catus	LARP1	VGNC	VGNC:63192
Macaca mulatta	LARP1	VGNC	VGNC:74160
Bos taurus	LARP1	VGNC	VGNC:30790
Canis familiaris	LARP1	VGNC	VGNC:42587

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LARP1 - La ribonucleoprotein 1, translational regulator Gene

关于 LARP1

功能概要

LARP1 基因产物(9)

LARP1 蛋白结构

LARP1 蛋白互作信息

关联疾病

直系同源

热门区域

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LARP1 - La ribonucleoprotein 1, translational regulator Gene

关于 LARP1

功能概要

LARP1 基因产物(9)

LARP1 蛋白结构

LARP1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z