1. Gene
  2. NCS1 - neuronal calcium sensor 1 Gene

NCS1 - neuronal calcium sensor 1 Gene

中文名称:神经元钙传感器 1

种属: Homo sapiens

同用名: FLUP; FREQ

基因 ID: 23413 | 基因类型: protein coding

关于 NCS1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:130,172,404-130,237,303 (from NCBI)

This gene has 3 transcripts (splice variants), 120 orthologues and 14 paralogues. Biased expression in brain (RPKM 60.4), esophagus (RPKM 14.4) and 11 other tissues.

功能概要

该基因是神经元钙传感器基因家族的成员,它编码主要在神经元中表达的钙结合蛋白。该基因编码的蛋白质以钙依赖性方式调节 G 蛋白偶联受体磷酸化,可替代钙调蛋白。该蛋白质与分泌颗粒相关并调节突触传递和突触可塑性。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2008 年 7 月]

This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for Calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NCS1 基因产物(2)

mRNA Protein Name
NM_001128826.2 NP_001122298.1 neuronal calcium sensor 1 isoform 2
NM_014286.4 NP_055101.2 neuronal calcium sensor 1 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12783849 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12783849 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12783849 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NCS1 蛋白结构

EF-hand_1

EF-hand_1: EF hand (68 - 90)

EF-hand_7

EF-hand_7: EF-hand domain pair (100 - 171)

  • 0
  • 100
  • 190 a.a.
蛋白主名 其他名称

neuronal calcium sensor 1

frequenin homolog

NCS1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NCS1 P62166 NBL1 Homo sapiens P41271
Validated Y2H
25416956
Intra NCS1 P62166 CEP89 Homo sapiens Q96ST8-3
Validated Y2H
32296183
Intra NCS1 P62166 CEP89 Homo sapiens Q96ST8-3
MAPPIT
32296183
Intra NCS1 P62166 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra NCS1 P62166 CTAG1A Homo sapiens P78358
Validated Y2H
32296183
Intra NCS1 P62166 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra NCS1 P62166 MIEF2 Homo sapiens Q96C03-3
Validated Y2H
32296183
Intra NCS1 P62166 SFTPA2 Homo sapiens Q8IWL1
Validated Y2H
32296183
Intra NCS1 P62166 SFTPA2 Homo sapiens Q8IWL1
Y2H Array
32296183
Intra NCS1 P62166 SFTPA2 Homo sapiens Q8IWL1
Y2H Prey Pooling
32296183
Intra NCS1 P62166 LY6G6D Homo sapiens O95868
Y2H Prey Pooling
32296183
Intra NCS1 P62166 LY6G6D Homo sapiens O95868
Y2H Array
32296183
Intra NCS1 P62166 OXER1 Homo sapiens Q8TDS5
Validated Y2H
32296183
Intra NCS1 P62166 OXER1 Homo sapiens Q8TDS5
Y2H Array
32296183
Intra NCS1 P62166 OXER1 Homo sapiens Q8TDS5
Y2H Prey Pooling
32296183
Intra NCS1 P62166 SIGLEC9 Homo sapiens Q9Y336
Validated Y2H
32296183
Intra NCS1 P62166 CREM Homo sapiens Q03060-25
Y2H Array
32296183
Intra NCS1 P62166 CREM Homo sapiens Q03060-25
Y2H Prey Pooling
32296183
Intra NCS1 P62166 CREM Homo sapiens Q03060-25
Validated Y2H
32296183
Intra NCS1 P62166 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra NCS1 P62166 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra NCS1 P62166 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra NCS1 P62166 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra NCS1 P62166 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra NCS1 P62166 RNASEH1 Homo sapiens O60930
Y2H Array
32296183
Intra NCS1 P62166 RNASEH1 Homo sapiens O60930
Y2H Prey Pooling
32296183
Intra NCS1 P62166 PRDM4 Homo sapiens Q9UKN5
Y2H Array
32296183
Intra NCS1 P62166 PRDM4 Homo sapiens Q9UKN5
Y2H Prey Pooling
32296183
Intra NCS1 P62166 PRDM4 Homo sapiens Q9UKN5
Validated Y2H
32296183
Intra NCS1 P62166 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Prey Pooling
32296183
Intra NCS1 P62166 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Array
32296183
Intra NCS1 P62166 C1QTNF2 Homo sapiens Q9BXJ5
Validated Y2H
32296183
Intra NCS1 P62166 SPRED2 Homo sapiens Q7Z698
Y2H Prey Pooling
32296183
Intra NCS1 P62166 SPRED2 Homo sapiens Q7Z698
Validated Y2H
32296183
Intra NCS1 P62166 SPRED2 Homo sapiens Q7Z698
Y2H Array
32296183
Intra NCS1 P62166 SPP1 Homo sapiens P10451
Y2H Array
32296183
Intra NCS1 P62166 SPP1 Homo sapiens P10451
Y2H Prey Pooling
32296183
Intra NCS1 P62166 DTX2 Homo sapiens Q86UW9
Validated Y2H
25416956
Intra NCS1 P62166 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Array
25416956
Intra NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Pooling
16189514
Intra NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H
21516116
Intra NCS1 P62166 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Wolfram Syndrome

Didmoad Syndrome

Didmoad

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Wfs

Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

Didmoadud

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Wolfram Syndrome 2

WFS2

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NCS1 RGD RGD:68417
Canis familiaris NCS1 VGNC VGNC:43667
Bos taurus NCS1 VGNC VGNC:31928
Felis catus NCS1 VGNC VGNC:63744
Mus musculus NCS1 MGD MGI:109166