1. Gene
  2. DDAH2 - dimethylarginine dimethylaminohydrolase 2 Gene

DDAH2 - dimethylarginine dimethylaminohydrolase 2 Gene

中文名称:二甲基精氨酸二甲基氨基水解酶 2

种属: Homo sapiens

同用名: G6a; DDAH; NG30; DDAHII; HEL-S-277

基因 ID: 23564 | 基因类型: protein coding

关于 DDAH2

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,727,040-31,730,263 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 188 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 29.0), fat (RPKM 28.2) and 24 other tissues.

功能概要

该基因编码二甲基精氨酸二甲基氨基水解酶。编码的酶通过调节甲基精氨酸的细胞浓度在一氧化氮生成中起作用,甲基精氨酸反过来抑制一氧化氮合酶活性。蛋白质可定位于线粒体。选择性剪接导致多个转录本变体。[RefSeq 提供,2014 年 12 月]

This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded Enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014]

DDAH2 基因产物(3)

mRNA Protein Name
NM_001303007.2 NP_001289936.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
NM_001303008.2 NP_001289937.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
NM_013974.3 NP_039268.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables dimethylargininase activity IDA
IDA: 通过直接分析推断
21493890 GOA
NOT enables dimethylargininase activity IGI
IGI: 通过遗传相互作用推断
37296100 GOA
NOT enables dimethylargininase activity IMP
IMP: 通过突变表型推断
37296100 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in citrulline metabolic process IDA
IDA: 通过直接分析推断
21493890 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DDAH2 蛋白结构

Amidinotransf

Amidinotransf: Amidinotransferase (36 - 279)

  • 0
  • 100
  • 200
  • 285 a.a.
蛋白主名 其他名称

N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

S-phase protein

DDAH2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DDAH2 O95865 IGFN1 Homo sapiens Q86VF2-5
Validated Y2H
32296183
Intra DDAH2 O95865 NOXA1 Homo sapiens Q86UR1-2
Validated Y2H
32296183
Intra DDAH2 O95865 FANCL Homo sapiens Q9NW38
Validated Y2H
32296183
Cross DDAH2 O95865 P0C6X7-PRO_0000037314 Human SARS coronavirus P0C6X7-PRO_0000037314
Y2H Pooling
22046132
Cross DDAH2 O95865 P0C6X7-PRO_0000037314 Human SARS coronavirus P0C6X7-PRO_0000037314
Lumier
22046132
Intra DDAH2 O95865 ACTN3 Homo sapiens Q08043
Validated Y2H
32296183
Intra DDAH2 O95865 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
Intra DDAH2 O95865 TRIP13 Homo sapiens Q15645
Validated Y2H
32296183
Intra DDAH2 O95865 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chronic Kidney Disease

Chronic Renal Disease

Chronic Kidney Failure

Ckd

Chronic Renal Failure

Kidney Failure, Chronic

Chronic Renal Failure Syndrome

Crf

Renal Failure - Chronic

Renal Failure Chronic

Chronic Kidney Diseases

Chronic Kidney Disease Stage 5

Ckd - [Chronic Kidney Disease]

Crf - [Chronic Renal Failure]

Chronic Kidney Impairment

Chronic Renal Impairment

Chronic Kidney Shutdown

Chronic Hypoxic Kidney Failure

Chronic Kidney Collapse

Chronic Renal Insufficiency

Chronic Kidney Toxaemia

Chronic Kidney Hypofunction

Chronic Renal Suppression

Chronic Renal Failure, Stage 5

Ckd - [Chronic Kidney Disease] Stage 5

End Stage Kidney Failure

End Stage Renal Failure

End Stage Kidney Disease

End Stage Renal Disease

End Stage Chronic Renal Failure

Esrf - [End Stage Renal Failure]

Esrd - [End Stage Renal Diseases]

Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²

Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Cardiovascular Disease

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Arteriosclerosis

Arteriosclerotic Vascular Disease

Pulmonary Hypertension

Primary Pulmonary Hypertension

Hypertension Pulmonary

Hypertension, Pulmonary

Hypertension, Pulmonary, Primary

Idiopathic Pulmonary Hypertension

Idiopathic Pulmonary Arterial Hypertension

Pulmonary Htn - [Hypertension]

Esophageal Lipoma

Lipoma Of Esophagus

Diabetes Mellitus

Diabetes

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus DDAH2 MGD MGI:1859016
Macaca mulatta DDAH2 VGNC VGNC:81057
Canis familiaris DDAH2 VGNC VGNC:39828
Bos taurus DDAH2 VGNC VGNC:27940
Felis catus DDAH2 VGNC VGNC:61385
Rattus norvegicus DDAH2 RGD RGD:1302955