TES - testin LIM domain protein Gene

中文名称：testin LIM 结构域蛋白

种属: Homo sapiens

同用名: TESS; TESS-2

关于 TES

功能概要

与癌症相关的染色体变化通常涉及包含脆弱位点的区域。该基因映射到染色体 7q31.2 上指定为 FRA7G 的常见脆弱位点。该基因类似于小鼠 Testin，一种睾酮反应基因，编码包含三个 LIM 结构域的支持细胞分泌蛋白。 LIM 域是双锌指基序，可介导转录因子、细胞骨架蛋白和信号蛋白之间的蛋白质-蛋白质相互作用。这种蛋白质是细胞生长的负调节剂，可作为肿瘤抑制因子。这种支架蛋白也可能在细胞粘附、细胞扩散和肌动蛋白细胞骨架的重组中发挥作用。多种蛋白质亚型由该基因的转录变体编码。[RefSeq 提供，2011 年 3 月]

Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin Cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]