2. Gene
  3. Brd7 - bromodomain containing 7 Gene

Brd7 - bromodomain containing 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含溴结构域 7

种属: Mus musculus

同用名: BP75; CELTIX1; Ptpn13ip

基因 ID: 26992 | 基因类型: protein coding

关于 Brd7

Chromosome 8: 89,057,667-89,088,822 reverse strand.GRCm39:CM001001.3

This gene has 7 transcripts (splice variants), 223 orthologues, 2 paralogues and is associated with 37 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 13.7), CNS E14 (RPKM 11.2) and 28 other tissues.

功能概要

该基因编码的蛋白可启动转录辅阻遏物活性。预计参与多个过程，包括有丝分裂细胞周期G1/S转换的负调控；组蛋白乙酰化的正调控；和转录调控，DNA 模板化。预测作用于 Wnt 信号通路的上游或内部。位于核内。以多种结构表达，包括中枢神经系统；泌尿生殖系统；肺;视网膜；和牙齿。该基因的人类直系同源物与急性髓性白血病有关。与人类 BRD7（含 7 的溴结构域）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of histone acetylation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within Wnt signaling pathway. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; lung; retina; and tooth. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7). [provided by Alliance of Genome Resources, Apr 2022]

Brd7 基因产物(6)

mRNA Protein Name
NM_001377014.1 NP_001363943.1 bromodomain-containing protein 7 isoform 3
NM_001377017.1 NP_001363946.1 bromodomain-containing protein 7 isoform 2
NM_001377015.1 NP_001363944.1 bromodomain-containing protein 7 isoform 4
NM_001377016.1 NP_001363945.1 bromodomain-containing protein 7 isoform 1
NM_001377013.1 NP_001363942.1 bromodomain-containing protein 7 isoform 2
NM_012047.3 NP_036177.1 bromodomain-containing protein 7 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10526152 MGI
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
19909775 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SWI/SNF superfamily-type complex IDA
IDA: 通过直接分析推断
24335282 MGI
located in nucleus IPI
IPI: 通过物理相互作用推断
10526152 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Brd7 蛋白结构

Bromo_brd7_like

Bromo_brd7_like: cd05513 (134 - 231)

DUF3512

DUF3512: pfam12024 (297 - 484)

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  • 651 a.a.
蛋白主名 其他名称

bromodomain-containing protein 7

75 kDa bromodomain protein

bromodomain protein 75 kDa

protein tyrosine phosphatase, non-receptor type 13 interacting protein

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114322 VZ185 Inhibitor 98.00% 否
HY-100352 BI-9564 Inhibitor 98.73% 否
HY-110374 NVS-CECR2-1 Inhibitor 99.40% 否
HY-100517 TP-472 Inhibitor 99.52% 否
HY-101121 NI-42 Inhibitor 99.53% 否
HY-116227 (2S,3R)-LP99 Inhibitor / 否
HY-149806 Bromodomain IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Brd7 NCBI NCBI:29117
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