2. Gene
  3. Parp2 - poly (ADP-ribose) polymerase 2 Gene

Parp2 - poly (ADP-ribose) polymerase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶 2

种属: Rattus norvegicus

同用名: Adprtl2

基因 ID: 290027 | 基因类型: protein coding

关于 Parp2

Primary_assembly 15: 24,034,106-24,044,338 forward strand.mRatBN7.2:CM026988.1

This gene has 2 transcripts (splice variants), 185 orthologues, 2 paralogues and is associated with 2 phenotypes.

功能概要

预测该基因编码的蛋白可启动核小体结合活性和戊糖基转移酶活性。参与神经元死亡的负调节和参与心肌细胞发育的细胞生长的正调节。预测位于核质和DNA损伤部位。预计在核仁中有活性。与人类 PARP2（聚（ADP-核糖）聚合酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable nucleosome binding activity and pentosyltransferase activity. Involved in negative regulation of neuron death and positive regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in nucleoplasm and site of DNA damage. Predicted to be active in nucleolus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Apr 2022]

Parp2 基因产物(1)

mRNA Protein Name
NM_001106030.1 NP_001099500.1 poly [ADP-ribose] polymerase 2
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in hippocampal neuron apoptotic process IMP
IMP: 通过突变表型推断
19422384 RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development IMP
IMP: 通过突变表型推断
23261455 RGD
involved in response to oxygen-glucose deprivation IMP
IMP: 通过突变表型推断
19422384 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

poly [ADP-ribose] polymerase 2

ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2

poly (ADP-ribose) polymerase family, member 2

相关产品

Approval
生物活性分子 (13)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10162 Olaparib Inhibitor 99.98% 是
HY-16106 Talazoparib Inhibitor 99.89% 否
HY-10619 Niraparib Inhibitor 99.96% 是
HY-10617A Rucaparib Inhibitor 99.97% 是
HY-10619B Niraparib tosylate Inhibitor 99.99% 是
HY-10619A Niraparib hydrochloride Inhibitor 99.41% 是
HY-10617 Rucaparib phosphate Inhibitor 99.76% 是
HY-102003 Rucaparib monocamsylate Inhibitor 99.82% 是
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% 是
HY-102003A Rucaparib camsylate Inhibitor / 否
HY-10617C Rucaparib tartrate Inhibitor / 否
HY-10617D Rucaparib acetate Inhibitor / 否
HY-10617B Rucaparib hydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (9)
目录号 产品名 作用方式
纯度 Phase
HY-122661 Mefuparib hydrochloride Inhibitor 98.94% Phase 4
HY-10129 Veliparib Inhibitor 99.92% Phase 3
HY-10130 Veliparib dihydrochloride Inhibitor 99.98% Phase 3
HY-132167 Saruparib Inhibitor 99.79% Phase 2
HY-12418 Stenoparib Inhibitor ≥98.0% Phase 2
HY-137457A Venadaparib hydrochloride Inhibitor / Phase 2
HY-105303 CEP-9722 Inhibitor / Phase 2
HY-13536 AZD-2461 Inhibitor 99.88% Phase 1
HY-115552 Simmiparib Inhibitor 99.51% Phase 1
Pre-clinical Phase
生物活性分子 (38)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15147 XAV-939 Inhibitor 99.91% 否
HY-13688A PJ34 Inhibitor 98.11% 否
HY-13990 NVP-TNKS656 Inhibitor 99.66% 否
HY-13688 PJ34 hydrochloride Inhibitor 99.91% 否
HY-150207 RBN-3143 Inhibitor 99.24% 否
HY-14478 UPF 1069 Inhibitor 99.10% 否
HY-12975 AZ6102 Inhibitor 99.65% 否
HY-100225 ME0328 Inhibitor 99.64% 否
HY-137457 Venadaparib Inhibitor 98.11% 否
HY-148566 OUL232 Inhibitor 99.86% 否
HY-18954 NMS-P118 Inhibitor 99.78% 否
HY-19351 MN-64 Inhibitor 99.61% 否
HY-132297A PARP1-IN-5 dihydrochloride Inhibitor 97.56% 否
HY-156419 PARP7-IN-16 Inhibitor 99.91% 否
HY-10614 A-966492 Inhibitor 99.95% 否
HY-108632 BYK204165 Inhibitor 98.66% 否
HY-148754 PARP10-IN-3 Inhibitor 98.89% 否
HY-143338 ART-IN-1 Inhibitor 98.91% 否
HY-156419A PARP7-IN-16 free base Inhibitor / 否
HY-121719 TIQ-A Inhibitor 99.65% 否
HY-155993 YCH1899 Inhibitor 99.39% 否
HY-149800 PARP-1-IN-3 Inhibitor 99.30% 否
HY-105692 DR2313 Inhibitor 99.66% 否
HY-102035 PARP-2-IN-1 Inhibitor 99.56% 否
HY-133124 PARP/PI3K-IN-1 Inhibitor 99.43% 否
HY-147886 PARP1-IN-11 Inhibitor 98.58% 否
HY-148753 PARP10-IN-2 Inhibitor 98.02% 否
HY-132297 PARP1-IN-5 Inhibitor / 否
HY-146336 PARP1/2/TNKS1/2-IN-1 Inhibitor / 否
HY-158334 NDs-IN-1 Inhibitor / 否
HY-W294889 OUL245 Inhibitor / 否
HY-169299 TOPOI/PARP-1-IN-2 Inhibitor / 否
HY-105253 PARP-2/1-IN-2 Inhibitor / 否
HY-100847 AZ0108 Inhibitor / 否
HY-145749 PARPYnD Inhibitor / 否
HY-161606 PARP-1/2/7-IN-1 Inhibitor / 否
HY-151625 PARP-2-IN-3 Inhibitor / 否
HY-14477 UPF-1035 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Parp2 NCBI NCBI:10038
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