2. Gene
  3. Nampt - nicotinamide phosphoribosyltransferase Gene

Nampt - nicotinamide phosphoribosyltransferase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：烟酰胺磷酸核糖转移酶

种属: Rattus norvegicus

同用名: Pbef; Pbef1

基因 ID: 297508 | 基因类型: protein coding

关于 Nampt

Primary_assembly 6: 49,424,332-49,462,100 forward strand.mRatBN7.2:CM026979.1

This gene has 4 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 20 phenotypes. Biased expression in Muscle (RPKM 673.5), Heart (RPKM 463.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括细胞因子活性；相同的蛋白质结合活性；和烟酰胺磷酸核糖转移酶活性。参与多个过程，包括对淀粉样蛋白-β 的细胞反应；细胞对缺氧葡萄糖的反应；和细胞衰老的负调节。位于细胞质中；核;和质膜。用于研究大脑中动脉梗塞和短暂性脑缺血。肾衰竭的生物标志物；牙周炎;和肺动脉高压。该基因的人类直系同源物与短暂性脑缺血有关。与人 NAMPT（烟酰胺磷酸核糖基转移酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including cytokine activity; identical protein binding activity; and nicotinamide phosphoribosyltransferase activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to oxygen-glucose deprivation; and negative regulation of cellular senescence. Located in cytoplasm; nucleus; and plasma membrane. Used to study middle cerebral artery infarction and transient cerebral ischemia. Biomarker of kidney failure; periodontitis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Nampt 基因产物(1)

mRNA Protein Name
NM_177928.3 NP_808789.1 nicotinamide phosphoribosyltransferase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine activity IDA
IDA: 通过直接分析推断
18768589 RGD
enables heterocyclic compound binding IDA
IDA: 通过直接分析推断
16901503 RGD
enables identical protein binding IDA
IDA: 通过直接分析推断
16901503 RGD
enables nicotinamide phosphoribosyltransferase activity IDA
IDA: 通过直接分析推断
4402158 RGD
enables nucleotide binding IDA
IDA: 通过直接分析推断
16901503 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to amyloid-beta IEP
IEP: 通过表达模式推断
28714019 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
28528966 RGD
involved in cellular response to ionizing radiation IEP
IEP: 通过表达模式推断
27681750 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
26547053 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
17641280 RGD
involved in microglial cell activation IMP
IMP: 通过突变表型推断
28528966 RGD
involved in negative regulation of autophagy IMP
IMP: 通过突变表型推断
26601421 RGD
involved in negative regulation of cellular senescence IDA
IDA: 通过直接分析推断
28125705 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
18952695 RGD
involved in regulation of lung blood pressure IMP
IMP: 通过突变表型推断
28438162 RGD
involved in response to D-galactose IEP
IEP: 通过表达模式推断
28163205 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
17418807 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Nampt 蛋白结构

PBEF_like

PBEF_like: cd01569 (27 - 436)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500 a.a.
蛋白主名 其他名称

nicotinamide phosphoribosyltransferase

NAmPRTase

pre-B-cell colony enhancing factor 1

pre-B-cell colony-enhancing factor 1 homolog

visfatin

相关产品

Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-50876 Daporinad Inhibitor 99.91% Phase 2
HY-12793 Padnarsertib Inhibitor 99.86% Phase 2
HY-10079 CHS-828 Inhibitor 99.74% Phase 1
HY-136241 OT-82 Inhibitor 99.84% Phase 1
HY-10080 Teglarinad chloride Inhibitor 98.77% Phase 1
Pre-clinical Phase
生物活性分子 (48)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126255 SBI-797812 Activator 99.74% 否
HY-144776 NAT Activator 99.56% 否
HY-15766 GNE-617 Inhibitor 99.69% 否
HY-12971 Nampt-IN-1 Inhibitor 99.48% 否
HY-12808 STF-118804 Inhibitor 99.72% 否
HY-12628 GNE-618 Inhibitor 99.89% 否
HY-148815 Nampt activator-1 Activator 98.42% 否
HY-148822 Nampt activator-2 Activator 98.80% 否
HY-148948 Nampt activator-3 Activator 99.67% 否
HY-161515 BRD4/NAMPT-IN-1 Inhibitor 99.45% 否
HY-112616 NAMPT inhibitor-linker 2 Inhibitor 98.11% 否
HY-147193 Nampt-IN-10 TFA Inhibitor 98.70% 否
HY-14374 GPP78 Inhibitor ≥99.0% 否
HY-152154 Nampt degrader-2 Inhibitor 99.41% 否
HY-15766A GNE-617 hydrochloride Inhibitor 99.16% 否
HY-14373 CB30865 Inhibitor 98.75% 否
HY-130606 Nampt-IN-5 Inhibitor 98.02% 否
HY-402237 Nampt-IN-15 Inhibitor / 否
HY-108701 Nampt-IN-3 Inhibitor 98.97% 否
HY-101280 LB-60-OF61 Inhibitor 99.25% 否
HY-14375 CB 300919 Inhibitor 98.01% 否
HY-101280A LB-60-OF61 hydrochloride Inhibitor / 否
HY-148572 NAMPT/IDO1-IN-1 Inhibitor / 否
HY-147756 Nampt-IN-7 Inhibitor / 否
HY-162124 HDAC/NAMPT-IN-1 Inhibitor / 否
HY-147795 Nampt-IN-8 Inhibitor / 否
HY-162519 LZFPN-90 Inhibitor / 否
HY-164759 Nampt-IN-13 Inhibitor / 否
HY-162269 Nampt activator-5 Activator / 否
HY-157421 Nampt activator-4 Modulator / 否
HY-147838 Nampt-IN-9 Inhibitor / 否
HY-163499 NAMPT activator-7 Activator / 否
HY-163500 NAMPT activator-8 Activator / 否
HY-163445 NAMPT activator-6 Activator / 否
HY-158319 Mutant IDH1/NAMPT-IN-1 Inhibitor / 否
HY-161051 Anticancer agent 177 Inhibitor / 否
HY-159009 MS7 Inhibitor / 否
HY-110319 (E/Z)-Daporinad hydrochloride Inhibitor / 否
HY-147656 NAMPT degrader-1 Inhibitor / 否
HY-162537 LYP-8 Inhibitor / 否
HY-147193A Nampt-IN-10 trihydrochloride Inhibitor / 否
HY-155506 NAMPT degrader-3 Degrader / 否
HY-163280 JGB-1-155 Activator / 否
HY-163440 PROTAC NAMPT Degrader-1 Degrader / 否
HY-164760 Nampt-IN-14 Inhibitor / 否
HY-125147 A-1293201 Inhibitor / 否
HY-161180 Antitumor agent-136 Inhibitor / 否
HY-10079A CHS-828 (nicotinate) Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nampt NCBI NCBI:10135
Mus musculus Nampt NCBI NCBI:59027
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z