Sirt5 - sirtuin 5 Gene

中文名称：沉默信息调节因子 2 相关酶类 5

种属: Rattus norvegicus

关于 Sirt5

功能概要

预测该基因编码的蛋白可启动 NAD+ 绑定活动；水解酶活性，作用于线性酰胺中的碳氮（但不是肽）键；和锌离子结合活性。参与心肌细胞凋亡过程的负调节和对营养水平的反应。预计位于线粒体内膜；线粒体膜间隙；和线粒体基质。预计在胞质溶胶和线粒体中具有活性。与人类 SIRT5（sirtuin 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable NAD+ binding activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and zinc ion binding activity. Involved in negative regulation of cardiac muscle cell apoptotic process and response to nutrient levels. Predicted to be located in mitochondrial inner membrane; mitochondrial intermembrane space; and mitochondrial matrix. Predicted to be active in cytosol and mitochondrion. Orthologous to human SIRT5 (Sirtuin 5). [provided by Alliance of Genome Resources, Apr 2022]