1. Gene
  2. ANXA6 - annexin A6 Gene

ANXA6 - annexin A6 Gene

中文名称:膜联蛋白 A6

种属: Homo sapiens

同用名: p68; p70; ANX6; CBP68; CPB-II

基因 ID: 309 | 基因类型: protein coding

关于 ANXA6

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:151,100,706-151,157,779 (from NCBI)

This gene has 16 transcripts (splice variants), 205 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 141.9), appendix (RPKM 77.0) and 24 other tissues.

功能概要

Annexin VI 属于钙依赖性膜和磷脂结合蛋白家族。膜联蛋白家族的几个成员与胞吐和胞吞途径的膜相关事件有关。 Annexin VI 基因长约 60 kbp,包含 26 个外显子。它编码一种约 68 kDa 的蛋白质,由八个 68 个氨基酸的重复序列组成,重复序列由可变长度的连接序列分隔。它与人膜联蛋白 I 和 II 序列高度相似,每个序列都包含四个这样的重复序列。膜联蛋白 VI 与介导胞吐过程中分泌上皮细胞的内体聚集和囊泡融合有关。已经描述了选择性剪接的转录物变体。[RefSeq 提供,2010 年 8 月]

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

ANXA6 基因产物(3)

mRNA Protein Name
NM_001155.5 NP_001146.2 annexin A6 isoform 1
NM_001193544.2 NP_001180473.1 annexin A6 isoform 2
NM_001363114.2 NP_001350043.1 annexin A6 isoform 3

ANXA6 蛋白结构

Annexin

Annexin: Annexin (24 - 89)

Annexin

Annexin: Annexin (97 - 161)

Annexin

Annexin: Annexin (179 - 244)

Annexin

Annexin: Annexin (255 - 320)

Annexin

Annexin: Annexin (368 - 432)

Annexin

Annexin: Annexin (439 - 504)

Annexin

Annexin: Annexin (527 - 593)

Annexin

Annexin: Annexin (604 - 668)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
蛋白主名 其他名称

annexin A6

67 kDa calelectrin

ANXA6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ANXA6 P08133 IL16 Homo sapiens Q14005-2 32296183
种属内
ANXA6 P08133 IL16 Homo sapiens Q14005-2 32296183
种属内
ANXA6 P08133 IL16 Homo sapiens Q14005-2 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ANXA6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7518 Annexin A6/ANXA6 Protein, Human (His) P08133 (A2-D673) ≥95%

关联疾病

疾病名称 别名
Kwashiorkor

Kwashiokor

Nutritional Edema With Dyspigmentation Of Skin And Hair

Nutritional Oedema With Dyspigmentation Of Skin And/Or Hair

Malignant Hyperthermia

Anesthesia Related Hyperthermia

Malignant Hyperpyrexia Due To Anesthesia

Hyperpyrexia, Malignant

Hyperthermia, Malignant

Malignant Hyperpyrexia

Mhs

Malignant Fever

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b

Lgmd2b

Lgmd3

Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency

Limb-Girdle Muscular Dystrophy Type 3

Muscular Dystrophy, Limb-Girdle, Type 2b

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ANXA6 RGD RGD:621172
Bos taurus ANXA6 VGNC VGNC:25968
Felis catus ANXA6 VGNC VGNC:67705
Macaca mulatta ANXA6 VGNC VGNC:69951
Mus musculus ANXA6 MGD MGI:88255
Canis familiaris ANXA6 VGNC VGNC:37943
Others ANXA6 NCBI