2. Gene
  3. ABLIM1 - actin binding LIM protein 1 Gene

ABLIM1 - actin binding LIM protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌动蛋白结合 LIM 蛋白 1

种属: Homo sapiens

同用名: ABLIM; LIMAB1; LIMATIN; abLIM-1

基因 ID: 3983 | 基因类型: protein coding

关于 ABLIM1

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:114,431,110-114,801,373 (from NCBI)

This gene has 14 transcripts (splice variants), 132 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 50.7), heart (RPKM 50.1) and 23 other tissues.

功能概要

该基因编码含有 LIM 锌结合域的蛋白质，该蛋白质结合肌动蛋白丝并介导肌动蛋白和细胞质靶点之间的相互作用。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2017 年 6 月]

This gene encodes a LIM zinc-binding domain-containing protein that binds to actin filaments and mediates interactions between actin and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2017]

ABLIM1 基因产物(26)

mRNA Protein Name
NM_001003407.2 NP_001003407.1 actin-binding LIM protein 1 isoform b
NM_001322882.2 NP_001309811.1 actin-binding LIM protein 1 isoform d
NM_001322883.2 NP_001309812.1 actin-binding LIM protein 1 isoform e
NM_001322884.3 NP_001309813.1 actin-binding LIM protein 1 isoform f
NM_001322885.3 NP_001309814.1 actin-binding LIM protein 1 isoform g
NM_001322886.3 NP_001309815.1 actin-binding LIM protein 1 isoform h
NM_001322887.2 NP_001309816.1 actin-binding LIM protein 1 isoform i
NM_001322888.2 NP_001309817.1 actin-binding LIM protein 1 isoform j
NM_001322889.2 NP_001309818.1 actin-binding LIM protein 1 isoform k
NM_001322890.2 NP_001309819.1 actin-binding LIM protein 1 isoform l
NM_001322891.2 NP_001309820.1 actin-binding LIM protein 1 isoform l
NM_001322892.2 NP_001309821.1 actin-binding LIM protein 1 isoform n
NM_001322893.2 NP_001309822.1 actin-binding LIM protein 1 isoform n
NM_001322894.2 NP_001309823.1 actin-binding LIM protein 1 isoform o
NM_001322895.2 NP_001309824.1 actin-binding LIM protein 1 isoform o
NM_001322896.2 NP_001309825.1 actin-binding LIM protein 1 isoform p
NM_001322897.2 NP_001309826.1 actin-binding LIM protein 1 isoform q
NM_001322898.2 NP_001309827.1 actin-binding LIM protein 1 isoform r
NM_001322899.2 NP_001309828.1 actin-binding LIM protein 1 isoform r
NM_001322900.2 NP_001309829.1 actin-binding LIM protein 1 isoform t
NM_001352440.1 NP_001339369.1 actin-binding LIM protein 1 isoform u
NM_001352441.1 NP_001339370.1 actin-binding LIM protein 1 isoform v
NM_001352442.2 NP_001339371.1 actin-binding LIM protein 1 isoform w
NM_001352443.2 NP_001339372.1 actin-binding LIM protein 1 isoform x
NM_002313.7 NP_002304.3 actin-binding LIM protein 1 isoform a
NM_006720.4 NP_006711.3 actin-binding LIM protein 1 isoform s
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15778465 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cilium assembly IMP
IMP: 通过突变表型推断
22684256 GOA
acts upstream of or within lamellipodium assembly IMP
IMP: 通过突变表型推断
22684256 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lamellipodium IDA
IDA: 通过直接分析推断
22684256 GOA
located in stress fiber IDA
IDA: 通过直接分析推断
22684256 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ABLIM1 蛋白结构

LIM

LIM: LIM domain (99 - 153)

LIM

LIM: LIM domain (158 - 209)

LIM

LIM: LIM domain (226 - 279)

LIM

LIM: LIM domain (285 - 328)

VHP

VHP: Villin headpiece domain (743 - 778)

  • 0
  • 200
  • 400
  • 600
  • 778 a.a.
蛋白主名 其他名称

actin-binding LIM protein 1

actin-binding LIM protein family member 1

ABLIM1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ABLIM1 O14639 YWHAZ Homo sapiens P63104
Anti Tag CoIP
33961781
种属内
ABLIM1 O14639 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
ABLIM1 O14639 SFN Homo sapiens P31947
TAP
15778465
种属内
ABLIM1 O14639 LDOC1 Homo sapiens O95751
Pull Down
16189514
种属内
ABLIM1 O14639 CARD9 Homo sapiens Q9H257
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spermatogenic Failure, Y-Linked, 2

SPGFY2

Spermatogenic Failure, Nonobstructive, Y-Linked

Y-Linked Spermatogenic Failure 2

Azoospermia, Nonobstructive, Y-Linked

Oligozoospermia, Nonobstructive, Y-Linked

Oligospermia, Nonobstructive, Y-Linked

Spermatogenic Arrest, Y-Linked

Nonobstructive Y-Linked Spermatogenic Failure

Spermatogenic Failure Y-Linked 2

Azoospermia Non-Obstructive Y-Linked

Non-Obstructive Azoospermia And Infertility

Oligospermia Non-Obstructive Y-Linked

Oligozoospermia Non-Obstructive Y-Linked

Spermatogenic Arrest Y-Linked

Spermatogenic Failure Nonobstructive Y-Linked
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00106 ABLIM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ABLIM1 VGNC VGNC:55931
Felis catus ABLIM1 VGNC VGNC:68486
Rattus norvegicus ABLIM1 RGD RGD:1565768
Macaca mulatta ABLIM1 VGNC VGNC:69587
Canis familiaris ABLIM1 VGNC VGNC:37478
Mus musculus ABLIM1 MGD MGI:1194500
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