LMO7 - LIM domain 7 Gene

中文名称：LIM 域 7

种属: Homo sapiens

同用名: LOMP; FBX20; LMO7b; FBXO20

基因 ID: 4008 | 基因类型: protein coding

关于 LMO7

Cytogenetic location: 13q22.2 Genomic coordinates (GRCh38): 13:75,620,434-75,859,870 (from NCBI)

This gene has 27 transcripts (splice variants), 326 orthologues and 1 paralogue. Broad expression in lung (RPKM 43.5), esophagus (RPKM 32.9) and 17 other tissues.

功能概要

该基因编码的蛋白质含有钙调蛋白同源 (CH) 结构域、PDZ 结构域和 LIM 结构域，可能参与蛋白质-蛋白质相互作用。已为该基因发现了几种编码不同亚型的可变剪接转录物变体，但是，一些变体的全长性质尚不清楚。[RefSeq 提供，2009 年 1 月]

This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]

LMO7 基因产物(8)

mRNA	Protein	Name
NM_001306080.2	NP_001293009.1	LIM domain only protein 7 isoform 3
NM_001330583.1	NP_001317512.1	LIM domain only protein 7 isoform 4
NM_001366632.2	NP_001353561.1	LIM domain only protein 7 isoform 2
NM_001366633.2	NP_001353562.1	LIM domain only protein 7 isoform 5
NM_001366634.2	NP_001353563.1	LIM domain only protein 7 isoform 6
NM_001366636.2	NP_001353565.1	LIM domain only protein 7 isoform 6
NM_005358.5	NP_005349.3	LIM domain only protein 7 isoform 1
NM_015842.2	NP_056667.2	LIM domain only protein 7 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15161933	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17067998	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	17067998	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17067998	GOA
located in nuclear envelope	IDA IDA: 通过直接分析推断	17067998	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17067998	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LMO7 蛋白结构

PDZ

0
300
600
900
1200
1385 a.a.

蛋白主名

其他名称

LIM domain only protein 7

F-box only protein 20

LMO7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LMO7	Q8WWI1	YWHAZ	Homo sapiens	P63104	Pull Down	15161933

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Townes-Brocks Syndrome

Townes Syndrome	Renal-Ear-Anal-Radial Syndrome
Anus, Imperforate, With Hand, Foot And Ear Anomalies	Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome
Rear Syndrome	Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs
Tbs	Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs
Imperforate Anus With Hand, Foot And Ear Anomalies	Anal-Ear-Renal-Radial Malformation Syndrome
Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Imperforate Anus-Hand And Foot Anomalies Syndrome
Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome	Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs

Hyperalphalipoproteinemia 1

Hyperalphalipoproteinemia	HALP1
Cetp Deficiency	Cholesterol-Ester Transfer Protein Deficiency
Familial Hyperalphalipoproteinemia	Cholesteryl Ester Transfer Protein Deficiency
Cept Deficiency	Cholesterol Ester Transfer Protein Deficiency

Cardiomyopathy, Dilated, 1dd

Dilated Cardiomyopathy 1dd	CMD1DD
Cardiomyopathy, Dilated 1dd	Cardiomyopathy, Dilated, Type 1dd

Astigmatism

Emery-Dreifuss Muscular Dystrophy 1, X-Linked

EDMD1	Emd1
Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures	X-Linked Emery-Dreifuss Muscular Dystrophy 1
Humeroperoneal Neuromuscular Disease	X-Linked Emery-Dreifuss Muscular Dystrophy
Scapuloperoneal Syndrome, X-Linked, Formerly	Humeroperoneal Neuromuscular Disease, Formerly
Scapuloperoneal Syndrome, X-Linked	Muscular Dystrophy Tardive Dreifuss-Emery Type With Contractures
Scapuloperoneal Syndrome X-Linked	X-Edmd
Dystrophy, Muscular, Emery-Dreifuss, Type 1, X-Linked

Emery-Dreifuss Muscular Dystrophy

Edmd	Emery-Dreifuss Syndrome
Muscular Dystrophy, Emery-Dreifuss	Humeroperoneal Neuromuscular Disease
Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures	Scapuloperoneal Syndrome, X-Linked
Benign Scapuloperoneal Muscular Dystrophy With Early Contractures	Muscular Dystrophy, Emery-Dreifuss Type
Muscular Dystrophy Emery-Dreifuss	Dystrophy, Muscular, Emery-Dreifuss
Emd - [Emery-Dreifuss Muscular Dystrophy]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07721	LMO7 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	LMO7	RGD	RGD:1302984
Felis catus	LMO7	VGNC	VGNC:68073
Mus musculus	LMO7	MGD	MGI:1353586
Bos taurus	LMO7	VGNC	VGNC:30937
Macaca mulatta	LMO7	VGNC	VGNC:74433
Canis familiaris	LMO7	VGNC	VGNC:42725

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