CDK18 - cyclin dependent kinase 18 Gene

中文名称：细胞周期蛋白依赖性激酶 18

种属: Homo sapiens

同用名: PCTK3; PCTAIRE; PCTAIRE3

基因 ID: 5129 | 基因类型: protein coding

关于 CDK18

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,504,669-205,532,790 (from NCBI)

This gene has 23 transcripts (splice variants), 198 orthologues and 26 paralogues. Broad expression in heart (RPKM 26.3), brain (RPKM 20.4) and 20 other tissues.

功能概要

预测启用 ATP 绑定活动；细胞周期蛋白依赖性蛋白丝氨酸/苏氨酸激酶活性；和蛋白丝氨酸激酶活性。预测参与有丝分裂细胞周期 G1/S 转换中涉及的蛋白质磷酸化和转录调节。预计在细胞质和细胞核中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ATP binding activity; cyclin-dependent protein serine/threonine kinase activity; and protein serine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CDK18 基因产物(3)

mRNA	Protein	Name
NM_002596.4	NP_002587.2	cyclin-dependent kinase 18 isoform b
NM_212502.3	NP_997667.1	cyclin-dependent kinase 18 isoform b
NM_212503.3	NP_997668.1	cyclin-dependent kinase 18 isoform a

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15161933	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of myelination	IDA IDA: 通过直接分析推断	31028571	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDK18 蛋白结构

Pkinase

0
100
200
300
400
504 a.a.

蛋白主名

其他名称

cyclin-dependent kinase 18

PCTAIRE protein kinase 3

CDK18 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDK18	Q07002	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
种属内	CDK18	Q07002	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956
种属内	CDK18	Q07002	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
种属内	CDK18	Q07002	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
种属内	CDK18	Q07002	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
种属内	CDK18	Q07002	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
种属内	CDK18	Q07002	ZNF774	Homo sapiens	Q6NX45	Validated Y2H	32296183
种属内	CDK18	Q07002	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	KRT34	Homo sapiens	O76011	Y2H Array	32296183
种属内	CDK18	Q07002	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
种属内	CDK18	Q07002	HOOK2	Homo sapiens	Q96ED9-2	Validated Y2H	32296183
种属内	CDK18	Q07002	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
种属内	CDK18	Q07002	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
种属内	CDK18	Q07002	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
种属内	CDK18	Q07002	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
种属内	CDK18	Q07002	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	CBY2	Homo sapiens	Q8NA61-2	Validated Y2H	32296183
种属内	CDK18	Q07002	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
种属内	CDK18	Q07002	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
种属内	CDK18	Q07002	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	FCHSD2	Homo sapiens	O94868-3	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	FCHSD2	Homo sapiens	O94868-3	Y2H Array	32296183
种属内	CDK18	Q07002	ZNF438	Homo sapiens	Q7Z4V0	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	ZNF438	Homo sapiens	Q7Z4V0	Validated Y2H	32296183
种属内	CDK18	Q07002	ZNF438	Homo sapiens	Q7Z4V0	Y2H Array	32296183
种属内	CDK18	Q07002	CCDC125	Homo sapiens	Q86Z20	Validated Y2H	32296183
种属内	CDK18	Q07002	CCDC125	Homo sapiens	Q86Z20	Y2H Array	32296183
种属内	CDK18	Q07002	CCDC125	Homo sapiens	Q86Z20	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	CCNK	Homo sapiens	O75909-2	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	CCNK	Homo sapiens	O75909-2	Y2H Array	32296183
种属内	CDK18	Q07002	VPS28	Homo sapiens	Q9UK41-2	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	VPS28	Homo sapiens	Q9UK41-2	Y2H Array	32296183
种属内	CDK18	Q07002	VPS28	Homo sapiens	Q9UK41-2	Validated Y2H	32296183
种属内	CDK18	Q07002	EYA2	Homo sapiens	O00167-2	Y2H Array	32296183
种属内	CDK18	Q07002	EYA2	Homo sapiens	O00167-2	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	PIBF1	Homo sapiens	Q4G0R1	Y2H Array	32296183
种属内	CDK18	Q07002	PIBF1	Homo sapiens	Q4G0R1	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	PIBF1	Homo sapiens	Q4G0R1	Validated Y2H	32296183
种属内	CDK18	Q07002	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
种属内	CDK18	Q07002	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
种属内	CDK18	Q07002	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
种属内	CDK18	Q07002	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
种属内	CDK18	Q07002	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
种属内	CDK18	Q07002	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
种属内	CDK18	Q07002	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	32296183
种属内	CDK18	Q07002	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	32296183
种属内	CDK18	Q07002	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
种属内	CDK18	Q07002	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
种属内	CDK18	Q07002	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	32296183
种属内	CDK18	Q07002	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
种属内	CDK18	Q07002	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	KRT75	Homo sapiens	O95678	Y2H Array	32296183
种属内	CDK18	Q07002	PNMA1	Homo sapiens	Q8ND90	Y2H Array	25416956
种属内	CDK18	Q07002	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
种属内	CDK18	Q07002	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
种属内	CDK18	Q07002	CCDC88B	Homo sapiens	A6NC98	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	CCDC88B	Homo sapiens	A6NC98	Y2H Array	32296183
种属内	CDK18	Q07002	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
种属内	CDK18	Q07002	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
种属内	CDK18	Q07002	KRT16	Homo sapiens	P08779	Y2H Array	32296183
种属内	CDK18	Q07002	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	CDK18	Q07002	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	TRAF1	Homo sapiens	Q13077	Validated Y2H	32296183
种属内	CDK18	Q07002	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
种属内	CDK18	Q07002	CCND3	Homo sapiens	P30281	Y2H Array	32296183
种属内	CDK18	Q07002	RABEP1	Homo sapiens	Q15276	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	RABEP1	Homo sapiens	Q15276	Validated Y2H	32296183
种属内	CDK18	Q07002	RABEP1	Homo sapiens	Q15276	Y2H Array	32296183
种属内	CDK18	Q07002	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
种属内	CDK18	Q07002	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
种属内	CDK18	Q07002	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	FSD2	Homo sapiens	A1L4K1	Y2H Array	32296183
种属内	CDK18	Q07002	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
种属内	CDK18	Q07002	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
种属内	CDK18	Q07002	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
种属内	CDK18	Q07002	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
种属内	CDK18	Q07002	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
种属内	CDK18	Q07002	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
种属内	CDK18	Q07002	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
种属内	CDK18	Q07002	HAP1	Homo sapiens	P54257	Y2H Array	32296183
种属内	CDK18	Q07002	HAP1	Homo sapiens	P54257	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
种属内	CDK18	Q07002	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
种属内	CDK18	Q07002	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
种属内	CDK18	Q07002	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	KRT15	Homo sapiens	P19012	Y2H Array	32296183
种属内	CDK18	Q07002	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
种属内	CDK18	Q07002	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
种属内	CDK18	Q07002	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	32296183
种属内	CDK18	Q07002	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Array	32296183
种属内	CDK18	Q07002	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	32296183
种属内	CDK18	Q07002	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
种属内	CDK18	Q07002	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
种属内	CDK18	Q07002	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
种属内	CDK18	Q07002	ZNF426	Homo sapiens	Q9BUY5	Validated Y2H	32296183
种属内	CDK18	Q07002	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	32296183
种属内	CDK18	Q07002	ZNF426	Homo sapiens	Q9BUY5	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	PPFIA1	Homo sapiens	Q13136	Validated Y2H	32296183
种属内	CDK18	Q07002	PPFIA1	Homo sapiens	Q13136	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	PPFIA1	Homo sapiens	Q13136	Y2H Array	32296183
种属内	CDK18	Q07002	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
种属内	CDK18	Q07002	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
种属内	CDK18	Q07002	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
种属内	CDK18	Q07002	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
种属内	CDK18	Q07002	CCNDBP1	Homo sapiens	O95273	Y2H Array	25416956
种属内	CDK18	Q07002	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956
种属内	CDK18	Q07002	AK8	Homo sapiens	Q96MA6	Validated Y2H	32296183
种属内	CDK18	Q07002	AK8	Homo sapiens	Q96MA6	Y2H Array	32296183
种属内	CDK18	Q07002	AK8	Homo sapiens	Q96MA6	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	TTC23	Homo sapiens	Q5W5X9-3	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183
种属内	CDK18	Q07002	TTC23	Homo sapiens	Q5W5X9-3	Y2H Array	32296183
种属内	CDK18	Q07002	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
种属内	CDK18	Q07002	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
种属内	CDK18	Q07002	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
种属内	CDK18	Q07002	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
种属内	CDK18	Q07002	TRIM50	Homo sapiens	Q86XT4	Validated Y2H	32296183
种属内	CDK18	Q07002	TRIM50	Homo sapiens	Q86XT4	Y2H Prey Pooling	32296183
种属内	CDK18	Q07002	TRIM50	Homo sapiens	Q86XT4	Y2H Array	32296183
种属内	CDK18	Q07002	KRT86	Homo sapiens	O43790	Y2H Array	32296183
种属内	CDK18	Q07002	KRT86	Homo sapiens	O43790	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02370	CDK18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CDK18	VGNC	VGNC:68737
Rattus norvegicus	CDK18	RGD	RGD:1309523
Bos taurus	CDK18	VGNC	VGNC:27121
Canis familiaris	CDK18	VGNC	VGNC:39049
Mus musculus	CDK18	MGD	MGI:97518
Macaca mulatta	CDK18	VGNC	VGNC:71162
Others	CDK18	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4