GALNT7 - polypeptide N-acetylgalactosaminyltransferase 7 Gene

中文名称：多肽 N-乙酰半乳糖氨基转移酶 7

种属: Homo sapiens

同用名: GalNAcT7; GALNAC-T7

关于 GALNT7

功能概要

该基因编码 GalNAc 转移酶 7，它是 GalNAc 转移酶家族的一员。由该基因编码的酶控制粘蛋白型 O-连接蛋白糖基化的起始步骤和 N-乙酰半乳糖胺向丝氨酸和苏氨酸氨基酸残基的转移。这种酶是一种 II 型跨膜蛋白，与其他家族成员共享共同的序列基序。与其他家族成员不同，该酶对部分 GalNAc 糖基化受体底物表现出专一性，对非糖基化肽没有活性。该蛋白质可作为 O-糖基化起始步骤中的后续酶发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The Enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This Enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this Enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated Peptides. This protein may function as a follow-up Enzyme in the initiation step of O-glycosylation. [provided by RefSeq, Jul 2008]