2. Gene
  3. TWSG1 - twisted gastrulation BMP signaling modulator 1 Gene

TWSG1 - twisted gastrulation BMP signaling modulator 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：扭曲的原肠胚形成 BMP 信号调制器 1

种属: Homo sapiens

同用名: TSG

基因 ID: 57045 | 基因类型: protein coding

关于 TWSG1

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,334,773-9,402,420 (from NCBI)

This gene has 3 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in endometrium (RPKM 35.8), gall bladder (RPKM 26.4) and 24 other tissues.

功能概要

启用转化生长因子 β 结合活性。参与多个过程，包括 CD4 阳性、α-β T 细胞增殖的负调节；通路限制性 SMAD 蛋白磷酸化的正调控；和转化生长因子β受体信号通路。预测位于细胞外区域。预计在细胞外空间活跃。 [由基因组资源联盟提供，2022 年 4 月]

Enables transforming growth factor beta binding activity. Involved in several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of pathway-restricted SMAD protein phosphorylation; and transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TWSG1 基因产物(1)

mRNA Protein Name
NM_020648.6 NP_065699.1 twisted gastrulation protein homolog 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables transforming growth factor beta binding IDA
IDA: 通过直接分析推断
17164348 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of CD4-positive, alpha-beta T cell activation IDA
IDA: 通过直接分析推断
17164348 GOA
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: 通过直接分析推断
17164348 GOA
involved in negative regulation of cytokine production IDA
IDA: 通过直接分析推断
17164348 GOA
involved in positive regulation of SMAD protein signal transduction IDA
IDA: 通过直接分析推断
17164348 GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
17164348 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TWSG1 蛋白结构

Tsg

Tsg: Twisted gastrulation (Tsg) protein conserved region (86 - 222)

  • 0
  • 100
  • 200
  • 223 a.a.
蛋白主名 其他名称

twisted gastrulation protein homolog 1

twisted gastrulation homolog 1

重组 TWSG1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71391 TWSG1 Protein, Human (HEK293, His) Q9GZX9-1 (C26-F223) ≥95%

关联疾病

疾病名称 别名
Breast Intraductal Papillomatosis

Breast Papillomatosis

Intraductal Papillomatosis Of The Breast
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]
Cataract 37

CTRCT37

Cca5

Cataract, Congenital, Cerulean Type, 5

Cataract 37, Autosomal Dominant

Congenital Cataract Cerulean Type 5
Prolapse Of Urethra

Urethrocele
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15284 TWSG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TWSG1 VGNC VGNC:48004
Mus musculus TWSG1 MGD MGI:2137520
Felis catus TWSG1 VGNC VGNC:66718
Bos taurus TWSG1 VGNC VGNC:36528
Macaca mulatta TWSG1 VGNC VGNC:104255
Rattus norvegicus TWSG1 RGD RGD:1311215
Others TWSG1 NCBI
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