2. Gene
  3. RNASE1 - ribonuclease A family member 1, pancreatic Gene

RNASE1 - ribonuclease A family member 1, pancreatic Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖核酸酶 A 家族成员 1，胰腺

种属: Homo sapiens

同用名: RAC1; RIB1; RNS1

基因 ID: 6035 | 基因类型: protein coding

关于 RNASE1

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,801,228-20,802,844 (from NCBI)

This gene has 5 transcripts (splice variants), 109 orthologues and 12 paralogues. Broad expression in pancreas (RPKM 931.1), testis (RPKM 410.8) and 19 other tissues.

功能概要

该基因编码胰腺型分泌性核糖核酸酶的一个成员，是核糖核酸酶 A 超家族的一个子集。编码的核酸内切酶切割嘧啶碱基 3'-侧的内部磷酸二酯 RNA 键。它更倾向于聚 (C) 作为底物并水解 2',3'-环核苷酸，最适 pH 值接近 8.0。编码的蛋白质是单体的，更常见的是降解 ds-RNA 而不是 ss-RNA。选择性剪接发生在该位点，并且已鉴定出编码相同蛋白质的四种转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded Endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

RNASE1 基因产物(4)

mRNA Protein Name
NM_002933.5 NP_002924.1 ribonuclease pancreatic precursor
NM_198232.3 NP_937875.1 ribonuclease pancreatic precursor
NM_198234.3 NP_937877.1 ribonuclease pancreatic precursor
NM_198235.3 NP_937878.1 ribonuclease pancreatic precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA nuclease activity IDA
IDA: 通过直接分析推断
9826755 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17350650 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in defense response to virus IDA
IDA: 通过直接分析推断
9826755 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNASE1 蛋白结构

RnaseA

RnaseA: Pancreatic ribonuclease (30 - 149)

  • 0
  • 100
  • 156 a.a.
蛋白主名 其他名称

ribonuclease pancreatic

HP-RNase

重组 RNASE1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71089 Rnase 1 Protein, Human (HEK293, His) P07998 (K29-T156) ≥95%
HY-P71089Y Rnase 1 Protein, Human (HEK293, His, solution) P07998 (K29-T156) ≥95%

关联疾病

疾病名称 别名
Mesothelioma, Malignant

Malignant Mesothelioma

Pleural Mesothelioma

MESOM

Mesothelioma, Somatic

Advanced Malignant Mesothelioma

Asbestos-Related Malignant Mesothelioma

Diffuse Malignant Mesothelioma

Malignant Tumor Of Mesothelium

Malignant Mesothelioma, Susceptibility To

Mesothelioma Diffuse Malignant

Mesothelioma

Malignant Pleural Mesothelioma
Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer

Hereditary Nonpolyposis Colorectal Cancer

Hereditary Nonpolyposis Colorectal Carcinoma

Hereditary Nonpolyposis Colorectal Neoplasms

Familial Nonpolyposis Colon Cancer

Hnpcc

Coca 1

Hereditary Defective Mismatch Repair Syndrome

Hereditary Non-Polyposis Colon Cancer

Hereditary Non-Polyposis Colon Cancer Syndrome

Hereditary Non-Polyposis Colorectal Cancer

Hereditary Non-Polyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colon Cancer Syndrome

Hereditary Nonpolyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colorectal Neoplasm

Hnpcc - Hereditary Nonpolyposis Colon Cancer

Cancer Family Syndrome

Familial Nonpolyposis Colorectal Cancer

Colon Cancer, Familial Nonpolyposis

Colorectal Neoplasms, Hereditary Nonpolyposis

Cancer, Colorectal, Nonpolyposis, Hereditary

Colorectal Cancer, Hereditary Nonpolyposis, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12018 RNASE1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RNASE1 VGNC VGNC:76700
Mus musculus RNASE1 MGD MGI:97919
Rattus norvegicus RNASE1 RGD RGD:3574
Others RNASE1 NCBI
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