2. Gene
  3. SCG5 - secretogranin V Gene

SCG5 - secretogranin V Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：分泌粒素 V

种属: Homo sapiens

同用名: 7B2; SgV; P7B2; SGNE1

基因 ID: 6447 | 基因类型: protein coding

关于 SCG5

Cytogenetic location: 15q13.3 Genomic coordinates (GRCh38): 15:32,641,710-32,697,092 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 201 orthologues. Biased expression in brain (RPKM 106.2), adrenal (RPKM 48.4) and 4 other tissues.

功能概要

该基因编码一种分泌性伴侣蛋白，可防止其他分泌性蛋白聚集，包括与神经退行性和代谢性疾病相关的蛋白。编码的蛋白质可能因其在激素原转化酶 PC2 (由基因 ID：5126 编码) 的运输和激活中的作用而广为人知。已显示编码蛋白的磷酸化对其伴侣功能具有抑制作用。该基因还产生 ARHGAP11A-SCG5 通读转录本和 ARHGAP11A-SCG5 蛋白。[RefSeq 提供，2019 年 2 月]

This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and Metabolic Disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]

SCG5 基因产物(4)

mRNA Protein Name
NM_001144757.3 NP_001138229.1 neuroendocrine protein 7B2 isoform 1 precursor
NM_001394278.1 NP_001381207.1 neuroendocrine protein 7B2 isoform 3 precursor
NM_001394279.1 NP_001381208.1 neuroendocrine protein 7B2 isoform 4 precursor
NM_003020.5 NP_003011.1 neuroendocrine protein 7B2 isoform 2 precursor

SCG5 蛋白结构

Secretogranin_V

Secretogranin_V: Neuroendocrine protein 7B2 precursor (Secretogranin V) (13 - 204)

  • 0
  • 100
  • 200
  • 212 a.a.
蛋白主名 其他名称

neuroendocrine protein 7B2

pituitary polypeptide

关联疾病

疾病名称 别名
Serous Labyrinthitis

Acute Serous Labyrinthitis
Hereditary Mixed Polyposis Syndrome

Hmps
Wolfram Syndrome

Didmoad Syndrome

Didmoad

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Wfs

Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

Didmoadud

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Lipoma Of Colon

Colonic Lipoma

Colon Lipoma
Large Intestine Lipoma

Lipoma Of Large Intestine

Colorectal Lipoma
Narcolepsy 1

NRCLP1

Narcoleptic Syndrome 1

Gelineau Disease

Narcolepsy-Cataplexy

Narcolepsy-Cataplexy Syndrome

Narcolepsy, Type 1

Narcolepsy Type 1

Cataplexy

Gélineau'S Syndrome

Narcolepsy With Cataplexy And/Or Hypocretin Deficiency
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12503 SCG5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SCG5 VGNC VGNC:34334
Rattus norvegicus SCG5 RGD RGD:3669
Felis catus SCG5 VGNC VGNC:64910
Canis familiaris SCG5 VGNC VGNC:45907
Mus musculus SCG5 MGD MGI:98289
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