SKP1 - S-phase kinase associated protein 1 Gene

中文名称：S 期激酶相关蛋白 1

种属: Homo sapiens

同用名: OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L

基因 ID: 6500 | 基因类型: protein coding

关于 SKP1

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,148,935-134,176,950 (from NCBI)

This gene has 13 transcripts (splice variants) and 244 orthologues. Ubiquitous expression in brain (RPKM 102.0), thyroid (RPKM 75.8) and 25 other tissues.

功能概要

该基因编码 SCF 复合物的一个成分，该复合物由该蛋白、cullin 1、一种环盒蛋白和 F-box 蛋白家族的一个成员组成。这种蛋白质直接与 F-box 蛋白质中的 F-box 基序结合。 SCF 复合物参与特定蛋白质底物的受调节泛素化，靶向它们以被蛋白体降解。特定的 F-box 蛋白识别不同的靶蛋白，并且已经确定了许多特定的 SCF 底物，包括细胞周期进程和发育的调节因子。研究还将该蛋白质表征为 RNA 聚合酶 II 延伸因子。该基因的可变剪接导致两种转录本变体。已在 7 号染色体上鉴定出一个相关的假基因。[RefSeq 提供，2008 年 7 月]

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]

SKP1 基因产物(2)

mRNA	Protein	Name
NM_006930.4	NP_008861.2	S-phase kinase-associated protein 1 isoform a
NM_170679.3	NP_733779.1	S-phase kinase-associated protein 1 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables F-box domain binding	IPI IPI: 通过物理相互作用推断	12820959	GOA
enables beta-catenin binding	IDA IDA: 通过直接分析推断	12820959	GOA
enables cullin family protein binding	IPI IPI: 通过物理相互作用推断	18929646	GOA
enables molecular function activator activity	IDA IDA: 通过直接分析推断	29997255	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11099048	GOA
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	15996101	GOA
enables ubiquitin ligase complex scaffold activity	IDA IDA: 通过直接分析推断	15145941	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: 通过直接分析推断	12820959	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	15103331	GOA
involved in chromatin remodeling	IDA IDA: 通过直接分析推断	16943429	GOA
involved in maintenance of protein location in nucleus	IPI IPI: 通过物理相互作用推断	21378169	GOA
involved in positive regulation of ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	12820959	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	15145941	GOA
involved in protein K48-linked ubiquitination	IDA IDA: 通过直接分析推断	15145941	GOA
involved in protein polyubiquitination	IDA IDA: 通过直接分析推断	12820959	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	15103331	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cul7-RING ubiquitin ligase complex	IDA IDA: 通过直接分析推断	18498745	GOA
part of PcG protein complex	IDA IDA: 通过直接分析推断	16943429	GOA
part of SCF ubiquitin ligase complex	IDA IDA: 通过直接分析推断	11956208	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	18929646	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18929646	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SKP1 蛋白结构

Skp1_POZ

Skp1

0
100
163 a.a.

蛋白主名

其他名称

S-phase kinase-associated protein 1

OCP-2

重组 SKP1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76644	SKP1 Protein, Human (Biotinylated, His-Avi)	P63208 (P2-K163)	≥95%

关联疾病

疾病名称

别名

Three M Syndrome 1

3-M Syndrome	Yakut Short Stature Syndrome
3m Syndrome	Le Merrer Syndrome
Dolichospondylic Dysplasia	Gloomy Face Syndrome
Three M Syndrome	3M1
3m Syndrome 1	Miller-Mckusick-Malvaux Syndrome
3-Msbn	Three-M Slender-Boned Nanism
Miller-Mckusick-Malvaux-Syndrome	3-M Syndrome 1
3m Syndrome-1	3m Syndrome, Type 1
Dwarfism	Dwarfism Tall Vertebrae

Mitochondrial Dna Depletion Syndrome 13

MTDPS13	Fbxl4 Deficiency
Fbxl4-Related Encephalomyopathic Mitochondrial Dna Depletion Syndrome	Mitochondrial Dna Depletion Syndrome 13, Encephalomyopathic Type
Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies	Mtdna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies
Fbxl4-Related Early-Onset Mitochondrial Encephalopathy	Mitochondrial Dna Depletion Syndrome 13 , Encephalomyopathic Type
Bxl4-Related Early-Onset Mitochondrial Encephalopathy	Encephalomyopathic Mitochondrial Dna Depletion Syndrome-13
Fbxl4-Related Early Onset Mitochondrial Encephalopathy	Mitochondrial Dna Depletion Syndrome, Type 13

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome	Pallidopyramidal Syndrome
Parkinson Disease 15, Autosomal Recessive	PARK15
Pkps	Pallido-Pyramidal Syndrome
Parkinson'S Disease 15	Autosomal Recessive Early-Onset Parkinson Disease 15
Autosomal Recessive Early-Onset Parkinson'S Disease 15	Pallido-Pyramidal Disease
Parkinson Disease 15	Parkinson Disease 15 Autosomal Recessive
Pps	Parkinson Disease, Type 15

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100237	SZL P1-41		99.92%	否
HY-10949	SMER3	Inhibitor	98.45%	否
HY-163019	EN884	Degrader	/	否
HY-RS12973	SKP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	SKP1	VGNC	VGNC:59042
Rattus norvegicus	SKP1	RGD	RGD:1359648
Mus musculus	SKP1	MGD	MGI:103575
Others	SKP1	NCBI

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