ZMYM2 - zinc finger MYM-type containing 2 Gene

中文名称：含锌指 MYM 型 2

种属: Homo sapiens

同用名: FIM; MYM; RAMP; SCLL; NECRC; ZNF198

基因 ID: 7750 | 基因类型: protein coding

关于 ZMYM2

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:19,863,840-20,089,115 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues, 18 paralogues and is associated with 78 phenotypes. Ubiquitous expression in testis (RPKM 14.1), thyroid (RPKM 6.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种锌指蛋白，可作为转录因子。编码的蛋白质可能是 BHC 组蛋白脱乙酰酶复合物的一部分。该基因与成纤维细胞生长因子受体 1 (FGFR1) 的易位导致融合基因，这可能是干细胞白血病淋巴瘤综合征 (SCLL) 的一个原因。已发现该基因的几种转录变体编码相同的蛋白质。[RefSeq 提供，2010 年 7 月]

The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the Fibroblast Growth Factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

ZMYM2 基因产物(11)

mRNA	Protein	Name
NM_001190964.4	NP_001177893.1	zinc finger MYM-type protein 2 isoform 1
NM_001190965.4	NP_001177894.1	zinc finger MYM-type protein 2 isoform 1
NM_001353157.2	NP_001340086.1	zinc finger MYM-type protein 2 isoform 1
NM_001353159.2	NP_001340088.1	zinc finger MYM-type protein 2 isoform 1
NM_001353161.3	NP_001340090.1	zinc finger MYM-type protein 2 isoform 2 precursor
NM_001353162.3	NP_001340091.1	zinc finger MYM-type protein 2 isoform 1
NM_001353163.2	NP_001340092.1	zinc finger MYM-type protein 2 isoform 3
NM_001353164.2	NP_001340093.1	zinc finger MYM-type protein 2 isoform 1
NM_001353165.2	NP_001340094.1	zinc finger MYM-type protein 2 isoform 4
NM_003453.6	NP_003444.1	zinc finger MYM-type protein 2 isoform 1
NM_197968.4	NP_932072.1	zinc finger MYM-type protein 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	26275350	GOA
enables ubiquitin conjugating enzyme binding	IPI IPI: 通过物理相互作用推断	12776193	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	32891193	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in PML body	IDA IDA: 通过直接分析推断	17027752	GOA
located in nucleus	IDA IDA: 通过直接分析推断	32891193	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZMYM2 蛋白结构

zf-FCS

DUF3504

0
300
600
900
1200
1377 a.a.

蛋白主名

其他名称

zinc finger MYM-type protein 2

fused in myeloproliferative disorders protein

ZMYM2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ZMYM2	Q9UBW7	GTF2IRD1	Homo sapiens	Q9UHL9	Y2H	26275350
Intra	ZMYM2	Q9UBW7	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities

NECRC

Lymphoblastic Lymphoma

Lymphoma, Lymphoblastic	Lymphoma Lymphoblastic
Precursor Cell Lymphoblastic Lymphoma	Precursor Cell Lymphoblastic Leukemia Lymphoma

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Myeloid And Lymphoid Neoplasms Associated With Fgfr1 Abnormalities

Myeloproliferative Neoplasm

Myeloproliferative Disorder	Chronic Myeloproliferative Disease
Myeloproliferative Neoplasms	Chronic Myeloproliferative Disorder
Cmpd	Cmpd, U
Chronic Myeloproliferative Disorders	Mpd
Mpn	Myeloproliferative Disorders
Myeloproliferative Disease	Campomelic Dysplasia

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Myeloid And Lymphoid Neoplasms With Eosinophilia And Abnormalities Of Pdgfra, Pdgfrb, And Fgfr1

Myeloid And Lymphoid Neoplasms With Eosinophilia And Abnormalities Of Platelet-Derived Growth Factor Receptor Alpha , Platelet-Derived Growth Factor Receptor Beta , And Fibroblast Growth Factor Receptor-1 Are A Group Of Hematologic Neoplasms

Myeloid And Lymphoid Neoplasms With Eosinophilia And Rearrangement Of Pdgfra, Pdgfrb, Or Fgfr1, Or With Pcm1-Jak2

Chronic Eosinophilic Leukemia

Pdgfra-Associated Chronic Eosinophilic Leukemia

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16089	ZMYM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ZMYM2	RGD	RGD:1593255
Macaca mulatta	ZMYM2	VGNC	VGNC:78865
Felis catus	ZMYM2	VGNC	VGNC:67258
Mus musculus	ZMYM2	MGD	MGI:1923257
Canis familiaris	ZMYM2	VGNC	VGNC:48646
Bos taurus	ZMYM2	VGNC	VGNC:56646

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