MAD2L1BP - MAD2L1 binding protein Gene

中文名称：MAD2L1 结合蛋白

种属: Homo sapiens

同用名: CMT2

关于 MAD2L1BP

功能概要

由该基因编码的蛋白质被鉴定为 MAD2 有丝分裂停滞缺陷样 1 (MAD2/MAD2L1) 的结合蛋白。 MAD2 是纺锤体检查点的关键组成部分，它延迟后期的开始，直到所有着丝粒都附着在纺锤体上。这种蛋白质可能与纺锤体检查点相互作用并在晚期有丝分裂中协调细胞周期事件。已经观察到编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]