2. Gene
  3. ARHGAP44 - Rho GTPase activating protein 44 Gene

ARHGAP44 - Rho GTPase activating protein 44 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rho GTP 酶激活蛋白 44

种属: Homo sapiens

同用名: RICH2; NPC-A-10

基因 ID: 9912 | 基因类型: protein coding

关于 ARHGAP44

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:12,789,498-12,991,643 (from NCBI)

This gene has 11 transcripts (splice variants), 269 orthologues and 2 paralogues. Broad expression in brain (RPKM 18.3), colon (RPKM 17.1) and 20 other tissues.

功能概要

启用磷脂结合活性。预计参与多个过程，包括树突棘的修饰； Rac 蛋白信号转导的负调控；质膜结合细胞投射组织的调控。位于前缘膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables phospholipid binding activity. Predicted to be involved in several processes, including modification of dendritic spine; negative regulation of Rac protein signal transduction; and regulation of plasma membrane bounded cell projection organization. Located in leading edge membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARHGAP44 基因产物(5)

mRNA Protein Name
NM_001321164.2 NP_001308093.1 rho GTPase-activating protein 44 isoform 2
NM_001321166.2 NP_001308095.1 rho GTPase-activating protein 44 isoform 3
NM_001321167.2 NP_001308096.1 rho GTPase-activating protein 44 isoform 4
NM_001321168.2 NP_001308097.1 rho GTPase-activating protein 44 isoform 5
NM_014859.6 NP_055674.4 rho GTPase-activating protein 44 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phospholipid binding IDA
IDA: 通过直接分析推断
22750946 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19273615 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in leading edge membrane IDA
IDA: 通过直接分析推断
22750946 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGAP44 蛋白结构

BAR

BAR: BAR domain (1 - 241)

RhoGAP

RhoGAP: RhoGAP domain (271 - 415)

  • 0
  • 200
  • 400
  • 600
  • 818 a.a.
蛋白主名 其他名称

rho GTPase-activating protein 44

Rho-type GTPase-activating protein RICH2

关联疾病

疾病名称 别名
Apolipoprotein C-Iii Deficiency

Hyperalphalipoproteinemia 2

HALP2
Phobia, Specific

Specific Phobia

Simple Phobia

Phobia, Simple

Isolated Phobia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00937 ARHGAP44 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ARHGAP44 RGD RGD:1305664
Canis familiaris ARHGAP44 VGNC VGNC:38065
Felis catus ARHGAP44 VGNC VGNC:59893
Bos taurus ARHGAP44 VGNC VGNC:26097
Mus musculus ARHGAP44 MGD MGI:2144423
Macaca mulatta ARHGAP44 VGNC VGNC:99117
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