2. Academic Validation
  3. Anti-HIV lignans from Justicia procumbens

Anti-HIV lignans from Justicia procumbens

  • Chin J Nat Med. 2019 Dec;17(12):945-952. doi: 10.1016/S1875-5364(19)30117-7.
Xin-Ya Xu 1,  Dong-Ying Wang 2,  Chuen-Fai Ku 3,  Yang Zhao 3,  Han Cheng 4,  Kang-Lun Liu 3,  Li-Jun Rong 5,  Hong-Jie Zhang 6
Affiliations

Affiliations

  • 1 School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China; Institute of Marine Drugs, Guangxi University of Chinese Medicine, Guangxi 530200, China.
  • 2 School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China; College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China.
  • 3 School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.
  • 4 Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, IL 60612, United States.
  • 5 Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, IL 60612, United States. Electronic address: lijun@uic.edu.
  • 6 School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. Electronic address: zhanghj@hkbu.edu.hk.
PMID: 31882050 DOI: 10.1016/S1875-5364(19)30117-7
Abstract

Twenty-one Lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new Lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L-1 and a selective index (SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A (3) and diphyllin (8) demonstrated inhibitory activity against HIV-1 with IC50 values of 4.95 (SI > 6.2) and 0.38 μmol·L-1 (SI = 5.3), respectively.

Keywords

Anti-HIV-1 activity; Antiviral plant; Justicia procumbens; Lignans.

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