2. Academic Validation
  3. STAT5 promotes chronic pancreatitis by enhancing GM-CSF-dependent neutrophil augmentation

STAT5 promotes chronic pancreatitis by enhancing GM-CSF-dependent neutrophil augmentation

  • J Leukoc Biol. 2021 Aug;110(2):293-300. doi: 10.1002/JLB.3MA1020-647R.
Yuli Lin 1 2,  Yusheng Chen 3,  Wenxue Feng 4,  Junfeng Zhang 5,  Rong Hua 5,  Bo Yin 4,  Xuguang Yang 1
Affiliations

Affiliations

  • 1 Clinical Research Center, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • 2 Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
  • 3 Department of Pancreatic Surgery, Department of Oncology, Shanghai Pancreatic Cancer Institute, Fudan University, Shanghai, China.
  • 4 Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
  • 5 Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
PMID: 34184320 DOI: 10.1002/JLB.3MA1020-647R
Abstract

Chronic pancreatitis (CP) is a continuing or relapsing inflammatory disease of the pancreas, characterized by fibrosis of the whole tissue. The regulatory mechanisms of the immune microenvironment in the pathogenesis of CP are still not clear. Immune cells, especially myeloid cells, play an important role in the pathogenesis of pancreatitis. Understanding the regulatory mechanisms of immune infiltration has a significant impact on CP intervention. Here, we demonstrated that transcription factor STAT5 was involved in and critical for the progression of CP. Inflammatory stress could significantly increase the expression and activation of STAT5 during CP. STAT5 deficiency or inhibition contributed to alleviating pancreatic inflammation and fibrosis in CP mice. The increased neutrophil infiltration, mediated by up-regulated GM-CSF, was responsible for the pancreatitis-promoting activity of STAT5. Our investigation highlighted the importance of STAT5 in regulating the immune microenvironment of CP. Targeting STAT5 may hold distinct promise for clinical treatment to alleviate CP.

Keywords

GM-CSF; STAT5; chronic pancreatitis; neutrophils.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-101853
    98.39%, STAT5抑制剂
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