2. Academic Validation
  3. Hollow mesoporous organosilica nanoparticles reduced graphene oxide based nanosystem for multimodal image-guided photothermal/photodynamic/chemo combinational therapy triggered by near-infrared

Hollow mesoporous organosilica nanoparticles reduced graphene oxide based nanosystem for multimodal image-guided photothermal/photodynamic/chemo combinational therapy triggered by near-infrared

  • Cell Prolif. 2023 Mar 20;e13443. doi: 10.1111/cpr.13443.
Chenguang Zhang 1 2,  Yuting Cai 3,  Dang Pengrui 4,  Jiechen Wang 5 6 7,  Lu Wang 1 2,  Jiayun Xu 1 2,  Yuhan Wu 1 2,  Wenwen Liu 8,  Lili Chen 5 6 7,  Zhengtang Luo 3,  Feilong Deng 1 2
Affiliations

Affiliations

  • 1 Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
  • 2 Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
  • 3 Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Hong Kong, China.
  • 4 Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, China.
  • 5 Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 6 School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • 7 Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, China.
  • 8 Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, China.
PMID: 36941019 DOI: 10.1111/cpr.13443
Abstract

Developing a nanosystem that can perform multimodal imaging-guided combination therapy is highly desirable but challenging. In this study, we introduced multifunctional nanoparticles (NPs) consisting of graphene oxide-grafted hollow mesoporous organosilica loaded with the drug doxorubicin (DOX) and photosensitizers tetraphenylporphyrin (TPP). These NPs were encapsulated by thermosensitive liposomes that release their contents once the temperature exceeds a certain threshold. Metal oxide NPs grown on the graphene oxide (GO) surface served multiple roles, including enhancing photothermal efficiency, acting as contrast agents to improve magnetic resonance imaging, increasing the sensitivity and specificity of photoacoustic imaging, and catalysing hydrogen peroxide for the generation of Reactive Oxygen Species (ROS). When locally injected, the HMONs-rNGO@Fe3 O4 /MnOx@FA/DOX/TPP NPs effectively enriched in subcutaneous Hela cell tumour of mice. The photothermal/photodynamic/chemo combination therapy triggered by near-infrared (NIR) successfully suppressed the tumour without noticeable side effects. This study presented a unique approach to develop multimodal imaging-guided combination therapy for Cancer.

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