2. Immunology/Inflammation
  3. CD73
  4. Mupadolimab

Mupadolimab  (Synonyms: 莫帕利单抗; CPI-006)

目录号: HY-P99181 纯度: 99.43%
COA

摩尔计算器

Mupadolimab (CPI-006) 是一种 IgG1κ 人源化的 FcγR 结合缺陷抗 CD73 单抗，激活 CD73POS B 细胞。

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CAS No. : 2451856-97-4

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥6600
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Mupadolimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mupadolimab (CPI-006) is an IgG1κ humanized FcγR binding-deficient anti-CD73 monoclonal antibody (mAb) that activates CD73POS B cells[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target

CD73[1]
体外研究
(In Vitro)

Mupadolimab 可诱导与 B 细胞成熟和抗原呈递相关的标志物表达增加、向浆母细胞的形态转化以及 IgM 和 IgG[1]分泌增加。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mupadolimab 相关抗体:
体内研究
(In Vivo)

Mupadolimab (10 mg/kg；腹腔注射；每天一次，持续 15 天) 刺激 SARS-CoV-2 感染的 NSG-SGM3 小鼠的抗原特异性体液免疫[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSG-SGM3 mice, immunized with an emulsion of 50 μg full length spike protein from SARS-CoV-2 and Freund’s Incomplete Adjuvant subcutaneously on both the left and right flank (25 μg/side)[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection, daily for 15 days
Result: Mice treated with the drug made antibodies to the immunizing TS protein; but not to the control nucleocapsid SARS-CoV-2 viral protein.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

莫帕利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Mupadolimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mupadolimab2451856-97-4CPI-006莫帕利单抗CPI006CPI 006CD73ecto-5′-nucleotidase, NT5ECOVID-19SARS-CoV-2immunotherapyCD73POSInhibitorinhibitorinhibit

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