2. 重组蛋白
  3. Receptor Proteins
  4. Pattern Recognition Receptors
  5. AIM2-like receptors
  6. Absent In Melanoma 2 (AIM2)
  7. AIM2 蛋白, Human (sf9, GST)

AIM2 蛋白, Human (sf9, GST)

目录号: HY-P72816
产品使用指南

AIM2 蛋白是 IFI20X/IFI16 家族的成员，在细胞增殖和致瘤逆转中表现出潜在的调节功能。AIM2 由干扰素-γ 诱导，在免疫反应中发挥关键作用。AIM2 在淋巴结和阑尾等组织中显着表达，在多种细胞过程和免疫相关功能中发挥着重要作用。AIM2 蛋白, Human (sf9, GST) 是重组的 AIM2 蛋白，由 Sf9 insect cells 表达，带有 N-GST 标签。AIM2 蛋白, Human (sf9, GST) 全长 343 个氨基酸，分子量约为 ~65.2 kDa。

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描述

AIM2 Protein, a member of the IFI20X/IFI16 family, exhibits potential regulatory functions in cell proliferation and tumorigenic reversion. Induced by interferon-gamma, AIM2 plays a key role in immune responses. Notably expressed in tissues like lymph node and appendix, AIM2 is a significant player in diverse cellular processes and immune-related functions. AIM2 Protein, Human (sf9, GST) is the recombinant human-derived AIM2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of AIM2 Protein, Human (sf9, GST) is 343 a.a., with molecular weight of ~65.2 kDa.
研究背景

AIM2 蛋白是 IFI20X/IFI16 家族的成员，与致瘤逆转有关，并在细胞增殖中具有潜在的调节功能。AIM2 的表达由干扰素-γ 诱导，强调其参与免疫反应。由于在淋巴结 (RPKM 9.4)、阑尾 (RPKM 5.0) 和其他五种组织等组织中观察到了偏向表达，AIM2 在多种细胞过程和免疫相关功能中发挥着关键作用。
种属

Human
表达系统

Sf9 insect cells
标签

N-GST
蛋白编号

O14862/NP_004824.1 (M1-T343)
基因 ID
蛋白结构
N-term
GST
AIM2 (M1-T343)
Accession # NP_004824.1
C-term
同用名
Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2
氨基酸序列

MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT

分子量

Approximately 65.2 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

AIM2 Protein, Human (sf9, GST) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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