FABP4 蛋白, Mouse (His)

The FABP4 protein binds hormone receptors, fatty acids, and transports them. It regulates thermogenesis, brown fat cell differentiation, and response to lithium ion. It is located in the cytoplasm and nucleus, and is expressed in adipose tissue, CNS, genitourinary system, gut, and heart. It shares orthology with human FABP4. Biased expression is seen in subcutaneous and genital fat pads. FABP4 Protein, Mouse (His) is the recombinant mouse-derived FABP4 protein, expressed by E. coli , with N-His labeled tag. The total length of FABP4 Protein, Mouse (His) is 131 a.a., with molecular weight of ~15.63 kDa.

FABP4蛋白具有激素受体结合、长链脂肪酸结合和长链脂肪酸转运蛋白活性。它在运输长链脂肪酸方面发挥作用，并积极调节冷诱导的生热作用。它参与多种过程，包括棕色脂肪细胞分化、细胞对锂离子的反应以及氮化合物代谢的负调节。FABP4 位于细胞质和细胞核中，并在多种结构中表达，包括脂肪组织、中枢神经系统、泌尿生殖系统、肠道和心脏。它与人类 FABP4（脂肪酸结合蛋白 4）具有直系同源性。根据基因组资源联盟于 2022 年 4 月提供的信息，在成人皮下脂肪垫 (RPKM 1709.3)、成人生殖器脂肪垫 (RPKM 1107.4) 和其他四种组织中观察到 FABP4 的偏向表达。

Mouse

E. coli

N-His

NP_077717.1 (C2-A132)

11770  [NCBI]

CDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKVKSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYERA

Approximately 15.63 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 0.2 M NaCl, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.