HAMP 蛋白, Larimichthys crocea

HAMP protein is a key signaling molecule for iron homeostasis and cooperates with HFE to regulate intestinal iron absorption and macrophage iron storage. HAMP has significant antibacterial effects and shows strong antibacterial activity against Gram-negative bacteria such as Vibrio alginolyticus and Gram-positive bacteria such as Staphylococcus aureus. HAMP protein, Larimichthys crocea is the recombinant HAMP protein, expressed by E. coli , with tag free. The total length of HAMP protein, Larimichthys crocea is 21 a.a., with molecular weight of ~2.5 kDa.

HAMP 蛋白似乎作为维持铁稳态至关重要的信号分子，与 HFE 一起调节肠道铁吸收和巨噬细胞中铁储存。其抗菌特性引人注目，对多种革兰氏阴性菌（包括溶藻弧菌、河弧菌、哈维弧菌和副溶血弧菌）具有强大的抗菌活性，具有不同的最低抑制浓度 (MIC)。此外，HAMP 对革兰氏阳性菌（如蜡状芽孢杆菌、枯草芽孢杆菌、谷氨酸棒杆菌、藤黄杆菌、溶壁杆菌、金黄色葡萄球菌和表皮葡萄球菌）具有抗菌活性。此外，它对黑曲霉、禾谷镰刀菌和茄镰孢具有抗真菌活性，但对毕赤酵母 GS115 和白色念珠菌缺乏抗真菌作用。这些不同的活动强调了 HAMP 在针对微生物挑战的宿主防御机制中的多方面作用。

Others

E. coli

Tag Free

A1Z0M0 (R65-F85)

104926498  [NCBI]

RCRFCCRCCPRMRGCGICCRF

Approximately 2.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.