HDGF 蛋白, Human (His)

The HDGF protein acts as a transcriptional repressor and was previously thought to have mitogenic activity for fibroblasts and be a heparin-binding protein. However, recent studies have shown that it does not exhibit mitogenic activity for fibroblasts and does not bind heparin. HDGF Protein, Human (His) is the recombinant human-derived HDGF protein, expressed by E. coli , with C-6*His labeled tag.

肝细胞瘤衍生生长因子 (HDGF) 具有转录抑制因子和成纤维细胞有丝分裂因子的双重作用。虽然它作为转录调节的阻遏物，影响细胞过程，但它也表现出促有丝分裂活性，特别是对于成纤维细胞。HDGF 已被鉴定为肝素结合蛋白，这表明它参与与肝素的相互作用并可能调节细胞反应。然而，值得注意的是，存在相互矛盾的报道，一些研究表明 HDGF 缺乏成纤维细胞有丝分裂活性，并且不与肝素结合。这些发现强调了 HDGF 功能的复杂性，展示了其在转录控制、有丝分裂信号传导以及与肝素的潜在相互作用中的不同作用。

Human

E. coli

C-6*His

P51858-1 (M1-Y100)

3068  [NCBI]

MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGY

Approximately 14.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.