IL-22R alpha 1 蛋白, Human (HEK293, Fc)

IL-22R alpha 1 (IL22RA1) Protein is an IL-22 receptor. IL-22R alpha 1 Protein interacts with IL-22 to activate the JAK/STAT cascade thereby inhibits IL-22 mediated promotion of cell proliferation and anti-apoptosis. IL-22R alpha 1 Protein, Human (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region (H16-T228) with a Fc tag at the C-terminus^[1].

IL-22R α 1 (IL22RA1) 蛋白是一种单程 I 型膜蛋白。IL-22R α 1 在结肠、肝脏、肺、胰腺和肾脏中表达。IL-22R α 1 主要存在于上皮细胞和某些单核细胞亚群上，在其他免疫细胞上发现非常有限的 IL-22R α 1 表达^[1][2]。
不同物种的IL-22R α 1 的氨基酸序列差异很大（人、大鼠和犬之间的相似性低于85%）。
IL-22R α 1 是重要组成部分高亲和力 IL-22 受体通过 JAK/STAT 途径实现 IL-22 信号传导。IL-22R α 1 是形成的 IL-20 和 IL-24 受体之一的组成部分，并通过 STAT 激活发出信号。IL-22R α 1 介导 IL-24 抗血管生成活性以及 IL24 对内皮细胞管形成和分化的抑制作用^[2][3]。

1.Immobilized Human IL-22, His Tag at 2 μg/ml (100 μl/Well) on the plate. Dose response curve for Human IL-22R alpha 1, hFc Tag with the EC₅₀ of 10.2 ng/ml determined by ELISA.
2.Immobilized Human IL-22R alpha 1, hFc Tag at 0.5 μg/mL (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-IL-22R alpha 1 Antibody, hFc Tag with the EC₅₀ of 11.2-18.4 ng/ml determined by ELISA.

Human

HEK293

C-hFc

Q8N6P7 (H16-T228)

58985  [NCBI]

HAPEDPSDLLQHVKFQSSNFENILTWDSGPEGTPDTVYSIEYKTYGERDWVAKKGCQRITRKSCNLTVETGNLTELYYARVTAVSAGGRSATKMTDRFSSLQHTTLKPPDVTCISKVRSIQMIVHPTPTPIRAGDGHRLTLEDIFHDLFYHLELQVNRTYQMHLGGKQREYEFFGLTPDTEFLGTIMICVPTWAKESAPYMCRVKTLPDRTWT

60-68 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Cui X, et, al. IL22 furthers malignant transformation of rat mesenchymal stem cells, possibly in association with IL22RA1/STAT3 signaling. Oncol Rep. 2019 Apr;41(4):2148-2158.  [Content Brief]

  [2]. Kragstrup TW, et, al. The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis. Front Immunol. 2018 Sep 25;9:2226.  [Content Brief]

  [3]. Persaud L, et, al. Mechanism of Action and Applications of Interleukin 24 in Immunotherapy. Int J Mol Sci. 2016 Jun 2;17(6):869.  [Content Brief]