KDM6B 蛋白, Human (Sf9)

KDM6B protein is a histone demethylase targeting "Lys-27" of histone H3, which mainly affects the histone code. Demethylates H3 "Lys-27" to shape the epigenetic landscape. KDM6B Protein, Human (Sf9) is the recombinant human-derived KDM6B protein, expressed by Sf9 insect cells , with tag free. The total length of KDM6B Protein, Human (Sf9) is 496 a.a., .

KDM6B 蛋白是一种对组蛋白 H3 的“Lys-27”具有特异性的组蛋白去甲基化酶，多项研究证明，它在复杂的组蛋白密码中占据着核心地位。这种酶可使三甲基化和二甲基化 H3“Lys-27”去甲基化，在塑造表观遗传景观中发挥着关键作用。除了在组蛋白修饰中的作用之外，KDM6B 还成为后发育的关键调节因子，对 HOX 基因表达产生影响并促进发育过程。在炎症反应的背景下，KDM6B 在炎症过程中的巨噬细胞分化中发挥着至关重要的作用，影响基因表达和分化过程。此外，KDM6B 在染色质重塑中表现出不依赖于去甲基化酶的功能，作为 T-box 因子和包含 SMARCA4 的 SWI/SNF 重塑复合物之间的关键联系，从而调节 T-box 家族成员依赖性基因表达（通过相似性）。KDM6B 的多方面作用强调了其在染色质结构和基因表达动态调节中的重要性。

Human

Sf9 insect cells

Tag Free

O15054 (D1141-L1636)

/

56.4 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES, pH 7.5, 200 mM NaCl, 20% glycerol.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.