LRRC15 蛋白, Canine (HEK293, His)

LRRC15 protein actively modulates SARS-CoV-2 infectivity by directly interacting with the spike protein, inhibiting ACE2(+) cell infection. While not an entry receptor, LRRC15, expressed on nearby cells, sequesters virions, and its direct interaction with the spike protein's RBD domain leads to virion sequestration at the cell surface. LRRC15 Protein, Canine (HEK293, His) is the recombinant canine-derived LRRC15 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRRC15 Protein, Canine (HEK293, His) is 519 a.a., with molecular weight of 70-80 kDa.

LRRC15 蛋白通过与其刺突蛋白相互作用来调节 SARS-CoV-2 的感染性。它不作为 SARS-CoV-2 的进入受体，但相反，当在附近的细胞上表达时，它会隔离病毒粒子并以反式方式抑制 ACE2(+) 细胞的 SARS-CoV-2 感染。此外，LRRC15 蛋白直接与人类冠状病毒 SARS-CoV-2 刺突蛋白的 RBD 结构域相互作用，导致病毒粒子隔离在细胞表面。

Canine

HEK293

C-His

XP_005639692.2 (Y47-G565)

488041  [NCBI]

70-80 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.